GADD 153 Inhibitors

Common GADD 153 Inhibitors include, but are not limited to 4-Phenylbutyric acid CAS 1821-12-1, Tauroursodeoxycholic Acid, Sodium Salt CAS 14605-22-2, Salubrinal CAS 405060-95-9, Guanabenz acetate CAS 23256-50-0 and Resveratrol CAS 501-36-0.

Growth Arrest and DNA Damage-inducible protein 153 (GADD 153), also known as C/EBP Homologous Protein (CHOP), is a transcription factor that plays a pivotal role in cellular stress responses. It is a member of the C/EBP family and is predominantly expressed when cells undergo endoplasmic reticulum (ER) stress. Under normal cellular conditions, GADD 153 levels are low, but upon the induction of stress, such as during unfolded protein response (UPR) or nutrient deprivation, its expression is markedly upregulated. The upregulation of GADD 153 is indicative of prolonged ER stress and can lead to cellular pathways that result in apoptosis. Therefore, GADD 153 acts as a pro-apoptotic factor, making it a crucial player in determining cell fate under stress conditions.

GADD 153 inhibitors are chemical compounds specifically designed to downregulate or suppress the activity or expression of GADD 153. These inhibitors can act by directly interacting with GADD 153 or by modulating upstream signaling pathways responsible for its induction. By mitigating the function or levels of GADD 153, these inhibitors can effectively reduce the pro-apoptotic effects associated with excessive ER stress, offering protection to cells under adverse conditions. The development and study of GADD 153 inhibitors provide valuable insights into the intricate mechanisms governing cellular responses to stress. These compounds can serve as essential tools for researchers aiming to elucidate the precise roles of GADD 153 in various physiological and pathological contexts, paving the way for a deeper understanding of stress response mechanisms at the cellular level.