GABA T-1 Inhibitors

GABA T-1 inhibitors belong to a distinct chemical class characterized by their interaction with a specific enzyme in the central nervous system. This enzyme, known as GABA transaminase (GABA T-1), plays a pivotal role in the metabolism of γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA T-1 is responsible for catalyzing the conversion of GABA into another molecule, leading to its degradation and subsequent termination of inhibitory signaling. Inhibitors of GABA T-1 modulate this enzymatic activity, resulting in altered GABA metabolism and impacting the balance of inhibitory neurotransmission. The structural features and mechanisms through which these inhibitors interact with GABA T-1 contribute to their distinctive pharmacological profile within the realm of neuroactive compounds. By targeting the enzymatic process that governs GABA degradation, GABA T-1 inhibitors hold promise for their influence on neurological processes.