NNC 05-2090 hydrochloride CAS: 184845-43-0
MF: C27H30N2O2•HCl
MW: 451.01
A GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters.

NNC 05-2090 hydrochloride (CAS 184845-43-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Application: A GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters
CAS Number: 184845-43-0
Purity: ≥98%
Molecular Weight: 451.01
Molecular Formula: C27H30N2O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

NNC 05-2090 hydrochloride is a GABA uptake inhibitor; displays moderate selectivity for BGT-1 (mGAT-2) transporters. GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chlorde-dependent members that mediate the rapid removal of GABA. NNC 05-2090 hydrochloride also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively). NNC 05-2090 hydrochloride is an inhibitor of GABA T-1, GABA T-2 and GABA T-3.


References

1. Thomsen, C., et al. 1997. Br. J. Pharmacol. 120: 983-985. PMID: 9134205
2. Dalby, N.O., et al. 1997. Epilepsy Res. 28: 51-61. PMID: 9255599

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (13 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D ~1.62 (Predicted)
IC50 :
α1- receptors: IC50 = 0.27 µM; BGT-1: IC50 = 1.4 µM (human); GABA transporter 3: IC50 = 1.41 µM (mouse); D2-receptors: IC50 = 1.63 µM; GABA transporter 1: IC50 = 10.23 µM (mouse)
Ki Data :
BGT-1: Ki= 1.4 µM (human); GABA T-3: Ki= 15 µM (human); GABA T-1: Ki= 19 µM (human); GABA T-2: Ki= 41 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
18782760
MDL Number :
MFCD00952020
SMILES :
COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 12ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.