Gγ 3 Activators
Gγ 3 activators represent a distinctive class of chemical compounds characterized by their ability to modulate the Gγ 3 subunit within the G protein-coupled receptor (GPCR) signaling cascade. G proteins are pivotal components of cell signaling pathways, mediating responses to extracellular stimuli by transmitting signals from cell surface receptors to intracellular effectors. The G protein complex consists of three subunits: α, β, and γ. The Gγ 3 subunit, in particular, plays a crucial role in regulating the specificity and efficacy of GPCR signaling. Gγ 3 activators are designed to selectively engage with and modulate the activity of this specific subunit.
At the molecular level, Gγ 3 activators exert their influence by binding to the Gγ 3 subunit, inducing conformational changes that ultimately impact downstream signaling events. This class of compounds is characterized by a diverse range of chemical structures, each tailored to interact with the Gγ 3no info subunit in a precise manner. By fine-tuning the interactions at the Gγ 3 subunit, these activators can either enhance or attenuate the signaling output of specific GPCRs, thereby influencing cellular responses to various stimuli. The intricate regulation of GPCR signaling by Gγ 3 activators holds promise for advancing our understanding of cellular communication and may have implications in fields such as cell biology and signal transduction research. Continued exploration of the structural and mechanistic aspects of Gγ 3 activators is essential for unraveling the complexities of GPCR signaling and may open avenues for the development of novel tools to manipulate cellular responses for research purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate specific targets including components of the G protein complex, potentially enhancing Gγ3's association with its Gα and Gβ subunits, thus increasing its functional activity. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $255.00 | 1 | |
Pilocarpine is a muscarinic acetylcholine receptor M1 agonist. Activation of M1 receptors can lead to the activation of Gq proteins and subsequent signaling through phospholipase C (PLC). This can result in the activation of protein kinase C (PKC), which may phosphorylate and enhance the activity of Gγ3. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis toxin catalyzes the ADP-ribosylation of Gi alpha subunits, preventing their interaction with receptors. This modulates the balance of G protein signaling, potentially shifting the equilibrium towards Gs or Gq pathways, indirectly enhancing signaling events that could lead to the activation of Gγ3. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor that prevents the degradation of cAMP and cGMP. By increasing their levels, it can enhance the signaling through PKA or PKG, respectively, which in turn could lead to the phosphorylation and functional activation of proteins associated with Gγ3 signaling. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol is a non-selective cholinergic agonist that can activate muscarinic receptors linked to Gq proteins, leading to the activation of PLC and subsequent intracellular calcium release. This increase in calcium can activate calcium-dependent kinases, which may phosphorylate and enhance the activity of Gγ3. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP-ribose can serve as a substrate for ADP-ribosylation reactions, which are catalyzed by bacterial toxins like cholera and pertussis toxins. In the context of cellular signaling, this modification can alter the activity of G proteins and potentially enhance Gγ3 function by modulating its interaction with other G protein subunits. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
Aluminum fluoride acts as a phosphate analog and can stabilize the transition state of GTP hydrolysis, leading to activation of G proteins. This could enhance Gγ3 signaling by mimicking the activated state of G proteins, promoting the association of Gγ3 with other signaling proteins. | ||||||
Mastoparan | 72093-21-1 | sc-200831 | 1 mg | $99.00 | ||
Mastoparan is a wasp venom peptide that directly interacts with G protein alpha subunits, stimulating GDP/GTP exchange. This activation of G proteins could enhance the functional activity of Gγ3 by facilitating its association with downstream signaling partners and effectors. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates G protein-coupled S1P receptors. Through the activation of these receptors, S1P can influence various G protein-mediated signaling pathways, potentially leading to the enhanced functional activity of Gγ3 via alteredGγ3 Activators are an array of chemical compounds that directly or indirectly enhance the functional activity of the protein Gγ3 by influencing specific signaling pathways or cellular processes. Forskolin, by raising cAMP levels, leads to the activation of protein kinase A (PKA). The phosphorylation activity of PKA can enhance the functional assembly and signaling of Gγ3 by targeting components of the G protein complex. Similarly, Isoproterenol, acting as a beta-adrenergic receptor agonist, also elevates cAMP levels, which in turn activates PKA and hence may enhance Gγ3 signaling pathways. Cholera Toxin, through its action on the Gs alpha subunit, leads to a prolonged increase in cAMP, which can further enhance the activity of PKA and subsequent activation of Gγ3-associated pathways. | ||||||