G β1 Activateurs

Les activateurs G β 1 courants comprennent, entre autres, l'Iloprost CAS 78919-13-8, la Forskoline CAS 66575-29-9, l'acide rétinoïque, tous trans CAS 302-79-4, le FTY720 CAS 162359-56-0 et la 1α,25-Dihydroxyvitamine D3 CAS 32222-06-3.

G β1, a crucial subunit of heterotrimeric G proteins, plays an essential role in transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. Understanding and modulating its activity is of paramount importance for manipulating cellular responses. Several chemical compounds have been identified as activators of G β1, directly or indirectly influencing its expression and function. Iloprost, a prostacyclin analog, directly enhances G β1 by activating the prostacyclin receptor (IP receptor), triggering G β1-mediated signal transduction pathways. The immunomodulatory drug fingolimod (FTY720) directly activates G β1 by stimulating the sphingosine-1-phosphate receptor (S1P receptor). Dopamine, acting as a D1-type receptor agonist, directly increases G β1 by activating D1-type dopaminergic receptors. Carbachol, a muscarinic acetylcholine receptor agonist, directly activates G β1 by binding to muscarinic receptors.

Sphingosine-1-phosphate (S1P), a bioactive lipid, directly enhances G β1 by activating S1P receptors, triggering downstream signaling events. Isoproterenol, a β-adrenergic receptor agonist, directly enhances G β1 by activating β-adrenergic receptors. Lysophosphatidic acid (LPA), another bioactive lipid, directly increases G β1 by activating LPA receptors. Lithium chloride, through inhibition of GSK-3β, directly increases the stability and functional activity of G β1. Forskolin, an adenylyl cyclase activator, directly enhances G β1 receptors by increasing cAMP levels. Prostaglandin E1 (PGE1) directly increases G β1 by activating prostaglandin receptors. Serotonin, acting as a 5-HT1 receptor agonist, directly increases G β1 by activating 5-HT1 receptors. Norepinephrine, an α1-adrenergic receptor agonist, directly increases G β1 by activating α1-adrenergic receptors. Prostaglandin E2 (PGE2) directly increases G β1 by activating prostaglandin receptors.