G β1 Activators
G β1, a crucial subunit of heterotrimeric G proteins, plays a pivotal role in transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. Understanding and modulating its activity are of paramount importance for manipulating cellular responses. Several chemical compounds have been identified as activators of G β1, directly or indirectly influencing its expression and function. Iloprost, a prostacyclin analog, directly enhances G β1 by activating the prostacyclin receptor (IP receptor), initiating G β1-mediated signal transduction pathways. Fingolimod (FTY720), an immunomodulatory drug, directly activates G β1 through sphingosine-1-phosphate receptor (S1P receptor) stimulation. Dopamine, acting as a D1-like receptor agonist, directly enhances G β1 by activating D1-like dopamine receptors. Carbachol, a muscarinic acetylcholine receptor agonist, directly activates G β1 through muscarinic receptor binding.
Sphingosine-1-phosphate (S1P), a bioactive lipid, directly enhances G β1 by activating S1P receptors, initiating downstream signaling events. Isoproterenol, a β-adrenergic receptor agonist, directly enhances G β1 by activating β-adrenergic receptors. Lysophosphatidic acid (LPA), another bioactive lipid, directly enhances G β1 by activating LPA receptors. Lithium chloride, through GSK-3β inhibition, directly enhances G β1 stability and functional activity. Forskolin, an adenylyl cyclase activator, directly enhances G β1 by increasing cAMP levels. Prostaglandin E1 (PGE1) directly enhances G β1 by activating prostaglandin receptors. Serotonin, acting as a 5-HT1 receptor agonist, directly enhances G β1 by activating 5-HT1 receptors. Norepinephrine, an α1-adrenergic receptor agonist, directly enhances G β1 by activating α1-adrenergic receptors. Prostaglandin E2 (PGE2) directly enhances G β1 by activating prostaglandin receptors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost, a prostacyclin analog, directly enhances G β1 by activating the prostacyclin receptor (IP receptor). Upon binding, Iloprost stimulates G β1-mediated signal transduction pathways, leading to increased functional activity. The activation of the IP receptor triggers downstream signaling cascades involving G β1, ultimately enhancing its functional role in cellular responses. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, an adenylyl cyclase activator, directly enhances G β1 by increasing cAMP levels. By activating adenylyl cyclase, forskolin stimulates G β1-mediated signaling pathways, leading to increased functional activity. The elevation of cAMP levels by forskolin enhances the role of G β1 in cellular processes, contributing to its functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid plays a crucial role in cell differentiation and growth, potentially influencing the transcription of various genes, including Gβ1. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Fingolimod, an immunomodulatory drug, directly enhances G β1 by activating the sphingosine-1-phosphate receptor (S1P receptor). By binding to the S1P receptor, Fingolimod initiates G β1-mediated signaling pathways, resulting in increased functional activity. The activation of S1P receptors by Fingolimod enhances the role of G β1 in cellular processes, contributing to its functional activation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, acting as a D1-like receptor agonist, directly enhances G β1 by activating D1-like dopamine receptors. Upon receptor binding, dopamine stimulates G β1-mediated signaling cascades, leading to increased functional activity. The activation of D1-like receptors by dopamine enhances the role of G β1 in cellular responses, contributing to its functional activation. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This active form of vitamin D can bind to the vitamin D receptor, influencing the transcription of various genes, potentially including Gβ1. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $122.00 $281.00 $388.00 $683.00 $1428.00 $3060.00 | 12 | |
Carbachol, a muscarinic acetylcholine receptor agonist, directly enhances G β1 by activating muscarinic receptors. Upon binding, carbachol initiates G β1-mediated signaling pathways, leading to increased functional activity. The activation of muscarinic receptors by carbachol enhances the role of G β1 in cellular processes, contributing to its functional activation. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP activates protein kinase A, which can influence the transcription of various genes, potentially including Gβ1. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate (S1P), a bioactive lipid, directly enhances G β1 by activating S1P receptors. Upon binding to S1P receptors, S1P stimulates G β1-mediated signaling pathways, leading to increased functional activity. The activation of S1P receptors by S1P enhances the role of G β1 in cellular responses, contributing to its functional activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a β-adrenergic receptor agonist, directly enhances G β1 by activating β-adrenergic receptors. Upon binding, isoproterenol stimulates G β1-mediated signaling pathways, resulting in increased functional activity. The activation of β-adrenergic receptors by isoproterenol enhances the role of G β1 in cellular processes, contributing to its functional activation. | ||||||