Gα q Activators
Gα_q is a crucial component of G-protein-coupled receptor (GPCR) signaling, mediating cellular responses to various extracellular stimuli. While Gα_q is typically activated by ligand binding to GPCRs, several chemical modulators have been identified to influence Gα_q signaling. YM-254890 and UBO-QIC are selective inhibitors of Gα_q/11 signaling, suppressing downstream cascades initiated by Gα_q-coupled receptors. FR900359, a cyclic depsipeptide, also inhibits Gα_q/11 signaling, disrupting cellular responses mediated by Gα_q-coupled receptors.
Notably, Yoda1 is a small molecule activator of Gα_q/11, directly initiating downstream signaling cascades associated with Gα_q-coupled receptors. Edelfosine and Mastoparan activate Gα_q by interacting with lipid rafts and GPCRs, respectively, leading to downstream signaling and cellular responses. MrgX2 agonists, diacylglycerol (DAG), and specific peptides designed to activate Gα_q demonstrate diverse mechanisms for Gα_q activation. Additionally, the bacterial toxin PMT activates Gα_q through deamidation, resulting in constitutive activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
YM-254890 is a small molecule inhibitor of Gα_q/11 signaling. Its inhibitory action on Gα_q/11 leads to the suppression of downstream signaling pathways, affecting cellular responses mediated by Gα_q-coupled receptors. | ||||||
FR 900359 | 107530-18-7 | sc-507357 | 500 µg | $226.00 | ||
UBO-QIC is a selective inhibitor of Gα_q/11 signaling. By inhibiting Gα_q/11, UBO-QIC disrupts downstream signaling cascades, indirectly influencing cellular processes governed by Gα_q-coupled receptors. | ||||||
YODA 1 | 448947-81-7 | sc-507361 | 10 mg | $215.00 | ||
Yoda1 is a small molecule activator of Gα_q/11 signaling. Its specific action involves direct activation of Gα_q, leading to the initiation of downstream signaling cascades and cellular responses mediated by Gα_q-coupled receptors. | ||||||
ET-18-OCH3 | 77286-66-9 | sc-201021 sc-201021A sc-201021B sc-201021C sc-201021F | 5 mg 25 mg 50 mg 100 mg 1 g | $111.00 $436.00 $843.00 $1576.00 $3756.00 | 6 | |
Edelfosine has been reported to activate Gα_q-coupled receptors. Its specific mechanism involves interaction with lipid rafts, leading to the activation of Gα_q and subsequent downstream signaling pathways. | ||||||
Mastoparan | 72093-21-1 | sc-200831 | 1 mg | $99.00 | ||
Mastoparan is a peptide that activates Gα_q by interacting with G-protein coupled receptors (GPCRs). Its binding to GPCRs induces conformational changes in Gα_q, leading to the activation of downstream signaling pathways and cellular responses mediated by Gα_q-coupled receptors. | ||||||