FLJ13231 Inhibitors
The inhibitors of FLJ13231 function through various biochemical mechanisms to decrease its activity related to ciliogenesis and planar cell polarity. Kinase inhibitors disrupt phosphorylation events that are critical for the functional activity of FLJ13231, resulting in diminished ciliogenesis. By inhibiting ATP binding to kinases, these molecules prevent the transmission of signals necessary for the proper functioning of FLJ13231. Other compounds target pathways such as Wnt and Hedgehog, which are integral to the regulation of ciliogenesis. Inhibition of GSK-3β, a component of the Wnt pathway, can lead to downstream effects on microtubule stabilization, thus impacting FLJ13231's participation in this process. Similarly, blockage of Hedgehog signaling impedes the pathway's influence on ciliogenesis, thereby impacting FLJ13231's role.
Further, the activity of FLJ13231 can be indirectly influenced by inhibitors of signaling molecules like MAPK, mTOR, and small GTPases which are essential for cytoskeletal dynamics and cellular responses to polarity cues. Compounds that impede the p38 MAPK can interfere with cellular stress responses, thereby affecting FLJ13231's function. mTOR inhibitors, by dampening the protein synthesis and cell growth signals, can also influence the assembly of ciliary structures where FLJ13231 is involved. Inhibition of small GTPases, which play a pivotal role in the organization of the actin cytoskeleton, can disrupt the establishment of planar cell polarity and consequently affect the proper localization and function of FLJ13231. Furthermore, these inhibitors can also modulate the trafficking of vesicles and proteins to the ciliary base, a process that is crucial for ciliogenesis and, by extension, for the activity of FLJ13231 in this context.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that interferes with ATP binding to kinases. Inhibition of kinase activity can lead to reduced phosphorylation of FLJ13231, thereby decreasing its functional activity related to ciliogenesis and planar polarity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
An inhibitor of GSK-3β which plays a role in the Wnt signaling pathway. By inhibiting GSK-3β, the downstream effects on microtubule stabilization can indirectly influence FLJ13231's role in ciliogenesis. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that blocks the MAPK/ERK pathway. This inhibition might disrupt cellular signaling processes, indirectly affecting FLJ13231's involvement in ciliogenesis by altering cellular response to planar cell polarity signals. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
An inhibitor of the Hedgehog signaling pathway, which is implicated in the regulation of ciliogenesis. By inhibiting this pathway, cyclopamine can indirectly affect the functional activity of FLJ13231 in ciliogenesis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that may interfere with signaling pathways involved in cellular stress responses. Its inhibition can indirectly affect FLJ13231 function in ciliogenesis, as p38 MAPK is involved in cytoskeletal dynamics. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can suppress cell growth and proliferation. By inhibiting mTOR signaling, rapamycin may indirectly influence FLJ13231's role in ciliogenesis and cell polarity due to changes in cell size and shape. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that impedes actin cytoskeleton organization. Since the actin cytoskeleton is crucial for ciliogenesis and planar cell polarity, inhibition by Y-27632 can indirectly decrease FLJ13231's functional activity. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
A Rac1 inhibitor that impairs small GTPase signaling, which is important for actin cytoskeleton reorganization. By inhibiting Rac1, NSC 23766 may indirectly decrease FLJ13231's functional activity in establishing cell polarity. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
An inhibitor of Wnt/β-catenin signaling by stabilizing axin. Since Wnt signaling is involved in planar cell polarity, XAV939 may indirectly decrease FLJ13231's functional activity in ciliogenesis and planar polarity processes. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
An inhibitor of BMP signaling which can indirectly affect ciliogenesis and planar cell polarity. Since FLJ13231 is involved in these processes, inhibition of BMP signaling by this compound can decrease its functional activity. | ||||||