FKBP14 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and inhibits mTOR pathway. As the FKBP14 protein shares high homology with FKBP12, rapamycin could indirectly inhibit FKBP14's peptidyl-prolyl isomerase activity due to competitive binding. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin by binding to cyclophilins. As FKBP14 is a member of the immunophilin protein family, which includes cyclophilins, it's likely that Cyclosporin A might also bind to FKBP14, thereby inhibiting its activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPAR-gamma agonist, alters the mitochondrial function and may affect proteins involved in mitochondrial-associated pathways, including FKBP14, by altering the protein folding environment. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to Hsp90, inhibiting its chaperone function. As FKBP14 is a chaperone that assists in protein folding, the inhibition of Hsp90 could disrupt the protein folding process, indirectly affecting FKBP14's function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tautomycin is a PP1 and PP2A phosphatase inhibitor, and since phosphatase activity affects numerous signaling pathways, FKBP14's role in protein folding and cellular signaling could be indirectly inhibited by the disruption of phosphatase function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that could increase the levels of misfolded proteins, indirectly affecting FKBP14's role in proteostasis by overwhelming the protein folding machinery that FKBP14 is a part of. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a DNA crosslinker that triggers the DNA damage response. FKBP14's potential involvement in cellular stress responses could be indirectly inhibited by the activation of DNA damage pathways and the resulting cellular arrest. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts ER to Golgi transport. FKBP14, being localized to the ER, might have its function affected by the disruption in trafficking and protein processing within the ER. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the SERCA pump, leading to ER stress. FKBP14's chaperone activity within the ER might be indirectly inhibited by the ER stress and unfolded protein response initiated by thapsigargin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to disrupt multiple cellular signaling pathways including the inhibition of transcription factors and kinases. This broad-spectrum activity could indirectly affect FKBP14's role in cellular signaling and protein folding. | ||||||