Fibrocystin Inhibitors
Fibrocystin inhibitors belong to a unique and relatively specialized class of chemical compounds primarily designed to target a specific protein known as fibrocystin. These inhibitors are instrumental in biochemical and cellular research, as they aid in elucidating the function and regulation of fibrocystin within various biological processes. Fibrocystin, encoded by the PKHD1 gene, plays a critical role in the formation and maintenance of renal cilia and is associated with autosomal recessive polycystic kidney disease (ARPKD) when mutated. The development of fibrocystin inhibitors is grounded in the need to understand the molecular mechanisms underlying ciliary function and dysfunction.
Fibrocystin inhibitors are meticulously designed molecules that bind selectively to fibrocystin, disrupting its interactions with other cellular components or modulating its activity. This class of inhibitors typically comprises small molecules or peptides with structures tailored to interact with specific domains or functional sites of fibrocystin.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tolvaptan | 150683-30-0 | sc-364638 sc-364638A | 10 mg 50 mg | $125.00 $624.00 | ||
Antagonizes vasopressin receptor 2 (V2), reducing cyclic AMP levels and potentially limiting cyst growth related to abnormal fibrocystin function. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Activates AMP-activated protein kinase (AMPK), which can regulate cell growth and proliferation processes associated with cyst development. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR signaling, which is involved in cell growth and may influence cystogenesis linked to fibrocystin dysfunction. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various signaling pathways, including those involved in inflammation and cell proliferation, which can affect cyst formation. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Inhibits cyclooxygenase (COX) enzymes and might reduce inflammatory processes that can exacerbate cyst growth in the context of fibrocystin. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Inhibits cyclin-dependent kinases (CDKs) and can affect cell cycle progression, potentially impacting cyst growth associated with fibrocystin. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Modulates autophagy and lysosomal function, which can influence cellular processes relevant to the function of fibrocystin. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $55.00 $240.00 $333.00 $562.00 $988.00 | ||
A diuretic that decreases fluid retention and may indirectly affect cyst growth by reducing intratubular pressure. | ||||||
myo-Inositol | 87-89-8 | sc-202714 sc-202714A sc-202714B sc-202714C | 100 g 250 g 1 kg 5 kg | $80.00 $151.00 $275.00 $837.00 | ||
Affects osmoregulation and cell signaling, which may influence cyst formation and growth related to fibrocystin. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which are implicated in cyst growth mechanisms relevant to fibrocystin. | ||||||