Fibrocystin Activators
Fibrocystin Activators are a class of compounds that can influence cellular signaling pathways, resulting in the activation of Fibrocystin. Forskolin, by elevating cAMP levels, activates PKA, which can phosphorylate proteins related to Fibrocystin's pathways, leading to its functional activity. IBMX, through the inhibition of phosphodiesterases, also raises cAMP and cGMP levels, thus enhancing PKA and PKG activity that may indirectly activate Fibrocystin. GTPγS keeps GTPases active, influencing pathways where Fibrocystin operates, leading to its activation. U0126's inhibition of MEK in the MAPK pathway can result in the compensatory activation of Fibrocystin through alternative signaling routes. Inhibitors of phosphatases such as Okadaic Acid and Calyculin A increase phosphorylation levels in the cell, which can enhance the activity of Fibrocystin by maintaining proteins in a phosphorylated state that interact with or affect Fibrocystin's function.
ML-7, by inhibiting MLCK, potentially shifts signaling towards Fibrocystin's pathways, indirectly enhancing its activity. Anisomycin activates JNK, which can upregulate transcription factors and signaling pathways that lead to Fibrocystin activation. Thapsigargin, by increasing cytosolic calcium, activates calcium-dependent proteins that interact with Fibrocystin, thereby enhancing its activity. The PI3K pathway, when inhibited by compounds like LY294002, can adjust cellular signaling in a way that upregulates Fibrocystin activity within its relevant networks. PMA, through the activation of protein kinase C, phosphorylates proteins within the pathways that Fibrocystin is involved in, potentially enhancing its functional activity. Y-27632, a ROCK inhibitor, can lead to the activation of compensatory pathways that may include Fibrocystin's, resulting in its activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which leads to increased cAMP and cGMP by preventing their degradation. Higher levels of these cyclic nucleotides activate PKA and PKG, which can enhance Fibrocystin activity by phosphorylation of associated proteins. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
GTPγS is a non-hydrolysable analogue of GTP, maintaining GTPases in an active state. Active GTPases can modulate signaling pathways that Fibrocystin is a part of, leading to its activation through downstream signaling cascades. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, part of the MAPK pathway. Inhibition of MEK can lead to compensatory activation of alternative pathways, potentially upregulating the activity of Fibrocystin through interconnected signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels. This would prevent the dephosphorylation of proteins associated with Fibrocystin, thereby enhancing its activation state. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 inhibits myosin light chain kinase (MLCK), shifting regulation towards pathways that Fibrocystin is involved in, thereby indirectly enhancing its activity due to reduced competition in regulatory signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator which can lead to the activation of transcription factors that influence the signaling pathways Fibrocystin is involved in, thereby enhancing its functional activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causing an increase in cytosolic calcium levels. Elevated calcium can activate calcium-dependent proteins that interact with Fibrocystin, leading to its activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic Acid, Calyculin A is an inhibitor of PP1 and PP2A, increasing the phosphorylation state of proteins and enhancing pathways that lead to Fibrocystin activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to adjustments in cellular signaling pathways that compensate by upregulating Fibrocystin's activity within its relevant signaling networks. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C, which can phosphorylate proteins within the signaling pathways that Fibrocystin is involved in, potentially leading to enhanced activity of Fibrocystin. | ||||||