FGF-11 Activators
FGF-11 Activators encompass a range of chemical entities that amplify the functional activity of FGF-11 through several cellular signaling pathways without altering its expression levels. Forskolin plays a crucial role in this process by directly activating adenylyl cyclase, which increases intracellular cAMP levels and subsequently activates protein kinase A (PKA). The activation of PKA leads to the phosphorylation of various proteins, thereby potentiating the signaling mechanisms in which FGF-11 is involved. Another notable activator, Phorbol 12-myristate 13-acetate (PMA), enhances the activity of FGF-11 by activating protein kinase C (PKC), which phosphorylates a broad spectrum of proteins, potentially influencing the pathways associated with FGF-11. Epigallocatechin Gallate (EGCG), a potent antioxidant, inhibits protein kinases that can modify FGF-11 associated pathways, thus indirectly enhancing its functional activity. Sphingosine 1-phosphate, by activating G-protein coupled receptors, could lead to downstream effects that promote FGF-11's activity. Additionally, LY294002, a PI3K inhibitor, can influence the PI3K/AKT signaling pathway, which may have downstream effects on FGF-11's activity.
The functional activity of FGF-11 is also modulated by compounds that affect cytoskeletal dynamics and protein phosphorylation states. Y-27632, a ROCK kinase inhibitor, may enhance FGF-11's activity by altering actin cytoskeleton regulation. Staurosporine, a broad-spectrum kinase inhibitor, could lead to enhanced FGF-11 activity by modifying the kinase landscape within the cell. Inhibitors of phosphatases such as Calyculin A and Okadaic Acid prevent the dephosphorylation of proteins, potentially leading to sustained signaling activity involving FGF-11. Wiskostatin and Blebbistatin, which inhibit N-WASP and myosin II ATPase respectively, could also indirectly augment FGF-11 activity by affecting the dynamics of actin filaments. Lastly, Jasplakinolide, by stabilizing actin filaments and promoting polymerization, might influence the signaling cascades that include FGF-11, increasing its functional activity within the cellular environment. These activators, through their specific and varied effects on intracellular signaling pathways, collectively contribute to the enhancement of FGF-11's role in cellular communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various targets potentially involved in enhancing the functional activity of FGF-11 in cellular signaling processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a wide array of proteins. This phosphorylation can enhance the signaling cascades that FGF-11 is part of, thereby increasing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a potent antioxidant that can inhibit various protein kinases, potentially altering signaling pathways that FGF-11 is involved in, thereby indirectly enhancing its activity in the cell. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine 1-phosphate is a lipid signaling molecule that activates G-protein coupled receptors, potentially leading to downstream effects that enhance the functional activity of FGF-11 through altered signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to changes in the PI3K/AKT signaling pathway, which may have downstream effects on the functional activity of FGF-11, leading to its enhancement. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK kinase, which is involved in regulating the actin cytoskeleton. Inhibition of ROCK could lead to changes in cytoskeletal dynamics that enhance the activity of FGF-11. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can inhibit multiple kinases, potentially leading to altered signaling pathways that enhance the functional activity of FGF-11. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a phosphatase inhibitor that prevents the dephosphorylation of proteins, which could lead to sustained activation of signaling pathways involving FGF-11, thus enhancing its function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits certain serine/threonine phosphatases, leading to an increase in phosphorylated proteins and may indirectly enhance the activity of FGF-11 by affecting signaling pathways it is involved in. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin inhibits the N-WASP, which affects actin polymerization. Altered actin dynamics could enhance the functional activity of FGF-11 as the cell adapts to these changes. | ||||||