Fc ε RIγ Activators
Fc ε RIγ activators are a class of molecules that play a crucial role in the immune system, particularly in the context of allergic responses and immune cell signaling. These activators are primarily associated with the activation of the high-affinity immunoglobulin E (IgE) receptor, Fc ε RIγ, which is expressed on the surface of mast cells and basophils. Fc ε RIγ activators are essential for initiating a cascade of cellular events that culminate in the release of inflammatory mediators, such as histamine and cytokines, in response to the binding of allergens to IgE antibodies. This class of molecules acts as molecular switches, triggering downstream signaling pathways that lead to cellular degranulation and the subsequent release of pro-inflammatory substances.
At a molecular level, Fc ε RIγ activators can include a variety of substances, including antigens, allergens, or certain signaling molecules. When an allergen or antigen binds to IgE antibodies anchored to Fc ε RIγ receptors on mast cells or basophils, it induces a conformational change in the receptor complex. This change results in the phosphorylation of intracellular signaling molecules, such as Syk and Lyn kinases, which then propagate the signal further downstream.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $41.00 $133.00 $663.00 | 2 | |
Corticosteroids can modulate immune responses and might indirectly influence Fc ε RIγ activity by altering mast cell function and IgE-mediated responses. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that can affect T-cell activation, potentially indirectly influencing mast cell function and Fc ε RIγ activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate, used in chemotherapy and as an immunosuppressant, can indirectly influence Fc ε RIγ activity through its effects on immune cell function. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine, used in autoimmune conditions, can modulate immune responses, potentially affecting Fc ε RIγ activity indirectly. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can affect various cellular pathways and may indirectly influence Fc ε RIγ activity through its regulatory effects on immune responses and cell signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences various signaling pathways and could affect Fc ε RIγ activity indirectly through its impact on immune cell regulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Known to influence immune function, vitamin D3 may indirectly affect Fc ε RIγ activity through its regulatory effects on immune cells. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin affects multiple cellular pathways and can influence immune function, potentially affecting Fc ε RIγ activity indirectly through its broad regulatory effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, found in green tea, can modulate immune responses, potentially affecting Fc ε RIγ activity indirectly through its impact on cellular processes and immune modulation. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
As an antioxidant, N-acetylcysteine may affect immune cell function and thus could influence Fc ε RIγ activity indirectly through its role in modulating oxidative stress. | ||||||