Date published: 2025-12-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

FBXO45 Inhibitors

FBXO45 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of FBXO45, a protein involved in the regulation of protein degradation and cellular processes. FBXO45 is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system, a cellular machinery responsible for protein degradation. The F-box proteins, including FBXO45, are known for their ability to recognize specific proteins and mark them for degradation, allowing cells to tightly regulate protein levels. Inhibiting FBXO45 with these compounds is a valuable approach for researchers studying the protein's functions and its role in cellular processes. These inhibitors can be used as tools to dissect the molecular mechanisms underlying FBXO45-mediated protein degradation, shedding light on how this protein contributes to the regulation of various cellular functions. Researchers can use FBXO45 inhibitors to explore the specific substrates that FBXO45 targets for degradation and understand how alterations in its activity may impact cell signaling, cell cycle control, and other critical processes. By elucidating the functions of FBXO45, scientists can gain insights into fundamental cellular biology and potentially identify new avenues for research in areas such as cancer biology and drug development.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially affecting FBXO45's function indirectly.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Another proteasome inhibitor could potentially affect the action of FBXO45.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

An inhibitor of the proteolytic activity of the 20S proteasome.

Ixazomib

1072833-77-2sc-489103
sc-489103A
10 mg
50 mg
$311.00
$719.00
(0)

An inhibitor of the β5 site of the 20S proteasome.

Carfilzomib

868540-17-4sc-396755
5 mg
$40.00
(0)

A proteasome inhibitor that affects the proteolytic breakdown of ubiquitinated proteins.

Celastrol, Celastrus scandens

34157-83-0sc-202534
10 mg
$155.00
6
(1)

Known to inhibit the proteasome, but its direct effect on FBXO45 is unknown.