FBXO35 Activators

FBXO35, also known as F-box only protein 35, is a member of the F-box protein family, which is characterized by an approximately 40-amino-acid F-box motif. This motif is crucial for the protein's role in the ubiquitin-proteasome pathway, where F-box proteins often function as specificity factors for the SCF (SKP1-cullin-F-box) E3 ubiquitin ligase complex.The primary function of FBXO35 is to mediate the ubiquitination of target proteins, marking them for degradation by the 26S proteasome. This process is vital for various cellular processes, including cell cycle regulation, signal transduction, and transcriptional control. By targeting specific substrates for degradation, FBXO35 plays a role in maintaining protein homeostasis and regulating the abundance of key regulatory proteins within the cell.

FBXO35 has been studied in the context of its interaction with particular substrates. For example, it has been implicated in the regulation of cell proliferation through its interaction with specific cell cycle regulators. By mediating the degradation of these proteins, FBXO35 can influence cell cycle progression and, consequently, impact processes like cell growth and differentiation.Like other F-box proteins, FBXO35 interacts with SKP1, cullin, and Rbx1 to form the SCF complex. Through its F-box domain, FBXO35 recruits specific substrates to the SCF complex, facilitating their ubiquitination by the attached E2 ubiquitin-conjugating enzyme. The specificity of FBXO35 for its substrates is determined by additional protein-protein interaction domains that recognize and bind to specific degradation signals (degrons) within the target proteins.