FBXO24 Activators
FBXO24, or F-box protein 24, is a protein that in humans is encoded by the FBXO24 gene. It's a member of the F-box protein family, characterized by an approximately 40 amino acid motif known as the F-box, which is a critical component of the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin ligase complex.The SCF complex plays a key role in protein degradation, a fundamental process in cells. It's responsible for the ubiquitination of proteins, a process that tags them for degradation by the 26S proteasome. This means that FBXO24, as part of this complex, participates in the regulation of protein levels within the cell. This affects a wide array of cellular processes such as cell cycle progression, signal transduction, and stress response.
There are indications that FBXO24 might be involved in various pathological conditions, including cancer. Some studies suggest that FBXO24 could function as a tumor suppressor, as it has been implicated in the degradation of MYC, a protein often overexpressed in many types of cancer.In summary, FBXO24 is a member of the F-box protein family and plays a role in protein degradation as part of the SCF E3 ubiquitin ligase complex. Its potential involvement in cancer, possibly through the degradation of MYC, makes it an interesting target for further research in cancer biology. However, much remains to be discovered about the precise functions and targets of FBXO24.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is another proteasome inhibitor; by blocking proteasomal degradation, it may increase the expression of proteins involved in the ubiquitin-proteasome system. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA influences cell differentiation and may affect the expression of genes involved in cell cycle control and protein turnover. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can affect various signaling pathways and gene expression profiles, potentially regulating components of the ubiquitin-proteasome system. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which may activate PKA and influence the transcription of genes, perhaps including those coding for ubiquitin ligases. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 engages the vitamin D receptor, which can modulate gene expression, potentially impacting genes involved in protein degradation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, sodium butyrate may alter chromatin structure and gene expression, possibly affecting ubiquitin ligase components. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to affect a broad range of cellular pathways, including those that regulate gene expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin induces ER stress and the unfolded protein response, which might influence the expression of genes like FBXO24 involved in protein quality control. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts ER calcium stores, leading to ER stress and potentially enhancing the expression of genes involved in the ER-associated degradation pathway. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol activates estrogen receptors that can modulate gene transcription, potentially affecting ubiquitin ligase expression. | ||||||