FAM21B Inhibitors
The chemical class of FAM21B Inhibitors comprises a diverse array of compounds that can potentially inhibit the activity of the FAM21B protein, either directly or indirectly. FAM21B plays a crucial role in intracellular trafficking and vesicle formation through its association with the WASH complex, which regulates actin dynamics at endosomal membranes. Therefore, inhibitors targeting key regulators of endosomal trafficking pathways, such as phosphoinositide 3-kinases (PI3Ks), dynamin, and Rac GTPases, can indirectly inhibit FAM21B function by disrupting downstream signaling events that regulate its activity.
For example, compounds like wortmannin and dynasore can inhibit PI3K and dynamin, respectively, leading to disruption of endocytic trafficking pathways and interfering with FAM21B-mediated vesicle formation and sorting processes. Similarly, inhibitors targeting actin dynamics, such as latrunculin A, CK-666, and Cytochalasin D, can indirectly inhibit FAM21B by disrupting the actin polymerization necessary for WASH complex function and endosomal membrane remodeling. Additionally, selective inhibitors of Rac GTPases, such as NSC23766 and EHop-016, can interfere with FAM21B-mediated actin dynamics and vesicle trafficking pathways. Overall, these inhibitors represent valuable tools for investigating the cellular functions of FAM21B.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks), enzymes involved in various cellular processes including vesicle trafficking. FAM21B is associated with the WASH complex, which regulates endosomal sorting and recycling. Inhibition of PI3K by wortmannin can disrupt endosomal trafficking pathways, potentially inhibiting FAM21B function indirectly. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is a fungal metabolite that inhibits protein transport between the endoplasmic reticulum (ER) and Golgi apparatus. FAM21B participates in Golgi-associated vesicle trafficking through its interaction with the WASH complex. Inhibition of protein transport by brefeldin A can disrupt the function of FAM21B in regulating Golgi morphology and trafficking pathways. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A is a marine toxin that disrupts actin polymerization, leading to cytoskeletal destabilization. FAM21B interacts with the actin-nucleating WASH complex, which regulates actin dynamics at endosomal membranes. Inhibition of actin polymerization by latrunculin A can disrupt the function of FAM21B in modulating endosomal morphology and trafficking pathways, thereby inhibiting its activity indirectly. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a small molecule inhibitor of dynamin, a GTPase involved in clathrin-mediated endocytosis. FAM21B is associated with the WASH complex, which regulates endosomal sorting and recycling processes. Inhibition of dynamin by dynasore can disrupt endocytic trafficking pathways, potentially affecting the function of FAM21B in endosomal membrane remodeling and vesicle trafficking. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is a fungal metabolite that disrupts actin polymerization by capping actin filaments. FAM21B is associated with the WASH complex, which modulates actin dynamics at endosomal membranes. Inhibition of actin polymerization by cytochalasin D can interfere with FAM21B-mediated regulation of endosomal morphology and trafficking pathways, resulting in indirect inhibition of its activity. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $78.00 | ||
EHop-016 is a selective inhibitor of Rac GTPase, which regulates actin cytoskeleton dynamics. FAM21B interacts with the WASH complex, which is involved in actin-mediated processes at endosomal membranes. Inhibition of Rac GTPase by EHop-016 can disrupt FAM21B-mediated actin polymerization, leading to alterations in endosomal morphology and trafficking pathways, thereby indirectly inhibiting its function. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $160.00 | ||
CK-869 is a potent and selective inhibitor of the actin-severing protein cofilin. FAM21B is associated with the WASH complex, which modulates actin dynamics at endosomal membranes. Inhibition of cofilin by CK-869 can interfere with FAM21B-mediated actin remodeling, leading to disruptions in endosomal morphology and trafficking pathways, thereby indirectly inhibiting its activity. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a selective inhibitor of myosin II ATPase activity, leading to inhibition of actin-myosin interactions and muscle contraction. FAM21B interacts with the WASH complex, which regulates actin dynamics at endosomal membranes. Inhibition of myosin II by blebbistatin can disrupt FAM21B-mediated actin remodeling, leading to alterations in endosomal morphology and trafficking pathways, thereby indirectly inhibiting its activity. | ||||||