FAM149A Activators
FAM149A Activators are a distinct set of chemical compounds that facilitate the enhancement of the functional activity of FAM149A through various signaling pathways and biological processes. Compounds like Forskolin and Isoproterenol function by raising intracellular cAMP levels, which in turn activate PKA. The activated PKA may then phosphorylate proteins within the same pathway as FAM149A, thereby enhancing its activity. Similarly, PMA, by activating PKC, and Ionomycin, by raising intracellular calcium levels, promote theactivation of signaling cascades in which FAM149A may be involved, indirectly leading to its increased functional activity. EGCG, through its inhibition of protein kinases, and the PI3K inhibitor LY294002, can shift cellular signaling dynamics, potentially enhancing pathways that include FAM149A. Additionally, by inhibiting MEK and p38 MAPK with U0126 and SB203580, respectively, alternative signaling pathways might be upregulated, potentially increasing the activity of FAM149A.
Furthermore, Sphingosine-1-phosphate and Thapsigargin, by modulating lipid and calcium signaling, respectively, can indirectly potentiate the functional activity of FAM149A through related pathways. Staurosporine, despite its broad kinase inhibitory properties, might inadvertently elevate FAM149A activity by releasing the inhibition of specific kinases on FAM149A-associated processes. Anisomycin, as a stress response activator, could also enhance FAM149A's activity by engaging cellular pathways that respond to stress, which may involve FAM149A. Collectively, these chemicals create a conducive environment for the activation of FAM149A by influencing various signaling molecules and pathways that, while not directly interacting with FAM149A, are sufficiently interconnected to enhance its functional activity without necessitating direct upregulation or modification of FAM149A itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins that are part of the same signaling pathways or cellular processes as FAM149A, indirectly increasing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases. By inhibiting competitive signaling routes, EGCG might enhance the functional activity of FAM149A by shifting the cellular signaling balance in favor of pathways that FAM149A is involved in. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that activates G-protein coupled receptors. This activation can lead to downstream signaling events that enhance the activity of FAM149A through related signaling cascades that involve lipid signaling molecules. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, which can indirectly enhance the activity of FAM149A if it is part of or regulated by these pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which could lead to the activation of alternative pathways that include FAM149A. By inhibiting PI3K, LY294002 can indirectly enhance the activity of FAM149A through a compensatory increase in signaling through other routes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor, and by inhibiting MEK, it can lead to the activation of alternative signaling pathways. This could enhance the activity of FAM149A if it is part of such alternative pathways that become upregulated when MEK is inhibited. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, which may lead to the enhancement of alternative signaling pathways that involve FAM149A. The inhibition of p38 MAPK could redirect signaling through pathways that FAM149A is a part of, increasing its functional activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. This can enhance the activity of FAM149A by activating calcium-dependent signaling pathways that FAM149A may be involved in. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist that increases intracellular cAMP levels. The resulting activation of PKA can enhance the activity of FAM149A by phosphorylating proteins in related signaling pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. While generally inhibitory, its complex effects on signaling networks could paradoxically enhance pathways involving FAM149A, by inhibiting kinases that normally downregulate pathways associated with FAM149A's activity. | ||||||