FAM134C Activators
Forskolin employs the elevation of cAMP to activate PKA, an enzyme capable of instigating a domino effect of phosphorylation events that could encompass FAM134C. Ionomycin, by raising intracellular calcium levels, sets the stage for calcium-dependent signaling pathways to alter the protein's milieu, indirectly affecting FAM134C's status in the cell. The activation of PKC by PMA represents another avenue, potentially modifying the phosphorylation state of proteins in close network proximity to FAM134C. Agents like 5-Azacytidine and Trichostatin A, which meddle with the epigenetic machinery, impact gene expression patterns and could upregulate proteins in FAM134C's entourage or even FAM134C itself. Retinoic Acid, engaging with nuclear receptors, also has the power to shift the transcriptional landscape in favor of proteins associated with FAM134C.
Inhibition, as much as activation, plays a critical role in the indirect modulation of FAM134C. The use of kinase inhibitors like SB 203580, LY294002, and PD98059 can recalibrate the MAPK and PI3K/AKT pathways, leading to a ripple effect impacting FAM134C. Likewise, mTOR signaling, intercepted by Rapamycin, creates an altered cellular environment that could intersect with FAM134C's regulatory framework. Moreover, the molecular maneuvering by Curcumin, affecting the NF-κB pathway, and Sodium Butyrate, altering histone acetylation, expand the repertoire of FAM134C's indirect activators by transforming the transcriptional terrain.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentrations, which can activate calcium-dependent signaling pathways, potentially influencing proteins linked to or interacting with FAM134C. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate a wide range of target proteins. PKC-mediated phosphorylation can affect proteins in the same pathway as FAM134C or directly influence FAM134C if it is a PKC substrate. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to gene demethylation. This can result in the upregulation of proteins, including those that may interact with or regulate FAM134C. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases, causing increased acetylation of histones and a more open chromatin state that can lead to upregulation of proteins, potentially including FAM134C or its modulators. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid binds to nuclear receptors altering gene transcription. This can lead to the expression of proteins involved in the same pathways as FAM134C or directly affect its expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor, which can lead to altered activity of MAPK pathway proteins. Changes in this pathway can influence the activity of FAM134C. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which can modulate the AKT signaling pathway and could affect proteins that interact with or regulate FAM134C. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which is a part of the MAPK/ERK pathway. Altering the activity of this pathway can influence FAM134C activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and proliferation. Changes in mTOR signaling can affect the activity of proteins in the same pathway as FAM134C or even FAM134C itself. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate the NF-κB pathway, which is involved in immune response and cell survival, potentially affecting the expression of proteins in the same pathway as FAM134C or directly influencing FAM134C expression. | ||||||