Date published: 2026-4-1

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FAM101A Inhibitors

Chemical inhibitors of FAM101A include a spectrum of compounds that interfere with various cellular processes and signaling pathways integral to the protein's function. Oligomycin A, for instance, targets the mitochondrial ATP synthase, a pivotal enzyme in energy production. Inhibition of ATP synthase by Oligomycin A can lead to reduced ATP levels, thereby hampering ATP-dependent functions of FAM101A. Concanamycin A disrupts cellular pH homeostasis by inhibiting vacuolar-type H+-ATPase, which can impede any pH-sensitive mechanisms that FAM101A may rely on. Similarly, Bortezomib disrupts proteasomal degradation pathways, leading to protein accumulation that can negatively impact FAM101A's associated pathways. Paclitaxel's role in stabilizing microtubules and hindering cell division could also indirectly inhibit FAM101A by disrupting cellular processes where FAM101A is implicated. Further, Dasatinib, a Src-family tyrosine kinase inhibitor, can obstruct downstream signaling that may involve FAM101A, leading to the protein's functional inhibition. The MEK1/2 inhibitor U0126 blocks the MAPK/ERK pathway, which, if FAM101A is involved, can inhibit its function. LY294002, a PI3K inhibitor, and Rapamycin, an mTOR inhibitor, can suppress the PI3K/Akt and mTOR pathways respectively, and therefore, they can inhibit FAM101A if it is part of those signaling cascades. Thapsigargin raises cytosolic calcium levels by inhibiting SERCA pumps, which could disrupt FAM101A activity if it is calcium-dependent. Staurosporine broadly targets kinases and can inhibit FAM101A by affecting kinase pathways that FAM101A is a component of. Pertussis Toxin's inactivation of Gi/o proteins can inhibit FAM101A if it is part of G-protein coupled receptor signaling. Lastly, SP600125, a JNK inhibitor, can inhibit FAM101A if the protein's activity is regulated by JNK-mediated phosphorylation events. Each inhibitor, by targeting a specific signaling pathway or cellular process, can contribute to the functional inhibition of FAM101A.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Oligomycin A

579-13-5sc-201551
sc-201551A
sc-201551B
sc-201551C
sc-201551D
5 mg
25 mg
100 mg
500 mg
1 g
$179.00
$612.00
$1203.00
$5202.00
$9364.00
26
(1)

Oligomycin A inhibits mitochondrial ATP synthase, which reduces ATP levels and consequently affects ATP-dependent pathways that FAM101A may be involved in, leading to functional inhibition of FAM101A's enzymatic activity.

Concanamycin A

80890-47-7sc-202111
sc-202111A
sc-202111B
sc-202111C
50 µg
200 µg
1 mg
5 mg
$66.00
$167.00
$673.00
$2601.00
109
(2)

Concanamycin A is a vacuolar-type H+-ATPase inhibitor, leading to disruption of proton gradients and cellular pH homeostasis, which can inhibit FAM101A's function that may rely on pH-sensitive mechanisms.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib inhibits the 26S proteasome, which can lead to an accumulation of polyubiquitinated proteins and possibly inhibit FAM101A by disrupting protein degradation pathways it may be involved in or reliant upon.

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$41.00
$74.00
$221.00
$247.00
$738.00
$1220.00
39
(2)

Paclitaxel stabilizes microtubules and can inhibit cell division. Disruption of cytoskeletal dynamics can indirectly inhibit FAM101A by affecting cellular processes that require FAM101A function for cell cycle progression.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Dasatinib is a Src-family tyrosine kinase inhibitor, and by inhibiting these kinases, it can disrupt downstream signaling pathways where FAM101A is involved, resulting in functional inhibition of FAM101A.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is an inhibitor of MEK1/2, which blocks the MAPK/ERK pathway. By inhibiting this pathway, it can functionally inhibit FAM101A if FAM101A is involved in cell signaling pathways that depend on MAPK/ERK signaling for activity.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor, which can inhibit the PI3K/Akt pathway. This inhibition can lead to functional inhibition of FAM101A if FAM101A's activity is connected to or dependent on the PI3K/Akt signaling pathway.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, which is involved in cell growth and proliferation. By inhibiting mTOR, Rapamycin can functionally inhibit FAM101A activity indirectly if FAM101A is involved in pathways or processes regulated by mTOR.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels. This disruption can inhibit FAM101A if FAM101A's function is calcium-dependent or if it operates in calcium-regulated pathways.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

Staurosporine is a potent kinase inhibitor and can functionally inhibit FAM101A by inhibiting kinases that phosphorylate FAM101A or kinases that are part of pathways where FAM101A is functionally active.