ETL Activators
ETL Activators include a range of compounds that indirectly augment the functional activity of ETL through modulation of intracellular signaling pathways, particularly those involving cyclic AMP (cAMP). Forskolin, Rolipram, and IBMX, through their actions on adenylyl cyclase and phosphodiesterases, lead to an increase in cAMP levels, which is a critical mediator in pathways where ETL is involved. This elevation in cAMP potentially enhances ETL's role in cellular signaling and trafficking. Similarly, epinephrine and isoproterenol, by stimulating adrenergic receptors, and dopamine, through its action on dopamine receptors, also raise cAMP levels. This increase in cAMP can further enhance ETL's activity, particularly in pathways related to stress responses, signal transduction, and receptor-mediated processes.
Continuing this theme, compounds like PGE2, adenosine, and histamine, which interact with their respective receptors, lead to increased cAMP levels, thereby potentially amplifying ETL's activity in immune response and cellular signaling pathways. Moreover, norepinephrine, salbutamol, and terbutaline, by activating adrenergic receptors, contribute to this cAMP elevation. The increase in cAMP levels can further enhance ETL's function in various physiological processes, including stress response, bronchodilation, and neurotransmission. These activators, through their targeted effects on cAMP and related signaling pathways, collectively facilitate the enhancement of ETL-mediated functions, highlighting the intricate network of cellular signaling in which ETL operates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can enhance ETL activity by stimulating pathways that influence ETL-mediated processes such as cellular signaling and trafficking. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, leading to increased cAMP levels. This can enhance ETL function by activating cAMP-dependent pathways that ETL is involved in, particularly in signal transduction. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a non-selective phosphodiesterase inhibitor, increases cAMP and cGMP levels, which may enhance ETL activity by influencing pathways associated with ETL in cellular signaling and communication. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, by binding to adrenergic receptors, can lead to increased cAMP levels, thereby potentially enhancing ETL activity in pathways related to stress response and signal transduction. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, increases cAMP levels, which could enhance ETL function in processes such as cell signaling and receptor-mediated pathways. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine through its action on dopamine receptors, can influence cAMP levels, potentially enhancing ETL activity in pathways related to neurotransmission and cellular communication. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2, by binding to its receptors, can increase cAMP levels. This elevation in cAMP may enhance ETL activity, particularly in pathways related to inflammation and immune response. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine, acting through adenosine receptors, increases cAMP levels, potentially enhancing ETL activity in processes like signal transduction and cellular response mechanisms. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through H2 receptors, can increase cAMP levels, potentially enhancing ETL function in pathways related to immune response and cellular signaling. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine, by activating adrenergic receptors, can elevate cAMP levels, potentially enhancing ETL activity in pathways related to stress response and neurotransmission. | ||||||