ErbB Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lapatinib ditosylate | 388082-78-8 | sc-202205B sc-202205 sc-202205A | 5 mg 10 mg 25 mg | $49.00 $77.00 $117.00 | 15 | |
Lapatinib ditosylate functions as a dual inhibitor of the ErbB receptor family, particularly targeting EGFR and HER2. Its unique structure facilitates specific interactions with the ATP-binding site, disrupting phosphorylation and subsequent signaling cascades. The compound exhibits distinct kinetic properties, allowing for competitive inhibition that alters receptor activation dynamics. Additionally, its solubility characteristics enhance bioavailability, influencing its distribution within cellular environments. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $420.00 | 32 | |
Lapatinib is characterized by its ability to selectively bind to the ATP-binding pocket of ErbB receptors, particularly EGFR and HER2, leading to a blockade of downstream signaling pathways. This compound exhibits unique conformational flexibility, enabling it to adapt to various receptor states. Its interaction kinetics reveal a competitive inhibition profile, which modulates receptor dimerization and activation. Furthermore, Lapatinib's lipophilic nature influences membrane permeability and cellular uptake, impacting its overall behavior in biological systems. | ||||||
Lapatinib-13C2,15N Ditosylate | sc-280905 | 500 µg | $330.00 | |||
Lapatinib-13C2,15N Ditosylate features a distinct isotopic labeling that enhances its tracking in metabolic studies. This compound exhibits unique binding dynamics with ErbB receptors, facilitating a nuanced understanding of receptor conformational changes. Its nitrogen incorporation allows for specific NMR studies, revealing insights into molecular interactions. Additionally, the presence of tosylate groups contributes to its solubility and stability, influencing its reactivity in various biochemical environments. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is a potent heat shock protein 90 (Hsp90) inhibitor that disrupts the chaperone function of Hsp90, leading to the destabilization of client proteins, including various oncogenic kinases. Its unique structure allows for selective binding to the ATP-binding pocket of Hsp90, altering the protein's conformational dynamics. This interaction triggers a cascade of proteasomal degradation, highlighting its role in modulating cellular stress responses and protein homeostasis. | ||||||
ErbB2 Inhibitor II | 928207-02-7 | sc-221592 | 5 mg | $290.00 | 2 | |
ErbB2 Inhibitor II selectively targets the ErbB2 receptor, disrupting its dimerization and subsequent signaling pathways. This compound exhibits high affinity for the receptor's extracellular domain, preventing ligand-induced activation. Its unique binding mechanism alters downstream signaling cascades, influencing cellular proliferation and survival. The inhibitor's kinetic profile reveals a rapid association and prolonged dissociation, underscoring its potential for sustained receptor modulation. | ||||||