Date published: 2025-10-21

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Endothelin Antibodies

Santa Cruz Biotechnology features a diverse variety of Endothelin Antibodies for investigating endothelins in physiological and pathological processes. Endothelin Antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Endothelins are potent vasoconstrictor peptides that play a critical role in regulating vascular tone and blood pressure. Beyond vascular regulation, endothelins influence cell proliferation, inflammation, and fibrosis processes. Cardiovascular research particularly benefits from studying endothelin functions, as they are implicated in conditions like hypertension and heart failure. Endothelin signaling pathways present numerous opportunities for therapeutic intervention in cardiovascular medicine. Understanding endothelin mechanisms can lead to breakthroughs in treating various vascular disorders. Researchers exploring endothelin biology can advance their work using Santa Cruz Biotechnology monoclonal antibodies, contributing to discoveries that may improve cardiovascular health outcomes.

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Endothelin Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Endothelin-1/EDN1/ET-1 Antibody (1C10)

sc-57116mouse IgG1 κ1-21 (h)ELISAh
1
(1)

Endothelin-2/EDN2/ET-2 Antibody (3B4-1C5)

sc-293248mouse IgG2b κFL (h)WB, IP, ELISAh
1
(2)

Endothelin-3/EDN3/ET-3 Antibody (5E8)

sc-81944mouse IgG1 κFL (h)WB, IP, ELISAh

new

(2)

pan ET Antibody (3G10)

sc-57396rat IgG2b(h)IFh

new

(1)

Endothelin CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Endothelin-1/EDN1/ET-1 CRISPR/Cas9 KO Plasmid (h)

sc-400564hGene KnockoutGFP0
(0)

Endothelin-1/EDN1/ET-1 HDR Plasmid (h)

sc-400564-HDRhHomology Directed RepairPuromycin0
(0)

Endothelin-1/EDN1/ET-1 Double Nickase Plasmid (h)

sc-400564-NIChGene KnockoutPuromycin0
(0)

Endothelin-1/EDN1/ET-1 Double Nickase Plasmid (h2)

sc-400564-NIC-2hGene KnockoutPuromycin0
(0)

Endothelin-1/EDN1/ET-1 CRISPR/Cas9 KO Plasmid (m)

sc-420108mGene KnockoutGFP0
(0)

Endothelin-1/EDN1/ET-1 HDR Plasmid (m)

sc-420108-HDRmHomology Directed RepairPuromycin0
(0)

Endothelin-1/EDN1/ET-1 Double Nickase Plasmid (m)

sc-420108-NICmGene KnockoutPuromycin0
(0)

Endothelin-1/EDN1/ET-1 Double Nickase Plasmid (m2)

sc-420108-NIC-2mGene KnockoutPuromycin0
(0)

Endothelin-2/EDN2/ET-2 CRISPR/Cas9 KO Plasmid (h)

sc-403871hGene KnockoutGFP0
(0)

Endothelin-2/EDN2/ET-2 HDR Plasmid (h)

sc-403871-HDRhHomology Directed RepairPuromycin0
(0)

Endothelin-2/EDN2/ET-2 Double Nickase Plasmid (h)

sc-403871-NIChGene KnockoutPuromycin0
(0)

Endothelin-2/EDN2/ET-2 Double Nickase Plasmid (h2)

sc-403871-NIC-2hGene KnockoutPuromycin0
(0)

Endothelin-2/EDN2/ET-2 CRISPR/Cas9 KO Plasmid (m)

sc-420109mGene KnockoutGFP0
(0)

Endothelin-2/EDN2/ET-2 HDR Plasmid (m)

sc-420109-HDRmHomology Directed RepairPuromycin0
(0)

Endothelin-2/EDN2/ET-2 Double Nickase Plasmid (m)

sc-420109-NICmGene KnockoutPuromycin0
(0)

Endothelin-2/EDN2/ET-2 Double Nickase Plasmid (m2)

sc-420109-NIC-2mGene KnockoutPuromycin0
(0)

Endothelin-3/EDN3/ET-3 CRISPR/Cas9 KO Plasmid (h)

sc-404436hGene KnockoutGFP0
(0)

Endothelin-3/EDN3/ET-3 HDR Plasmid (h)

sc-404436-HDRhHomology Directed RepairPuromycin0
(0)

Endothelin-3/EDN3/ET-3 Double Nickase Plasmid (h)

sc-404436-NIChGene KnockoutPuromycin0
(0)

Endothelin-3/EDN3/ET-3 Double Nickase Plasmid (h2)

sc-404436-NIC-2hGene KnockoutPuromycin0
(0)

Endothelin-3/EDN3/ET-3 CRISPR/Cas9 KO Plasmid (m)

sc-420110mGene KnockoutGFP0
(0)

Endothelin-3/EDN3/ET-3 HDR Plasmid (m)

sc-420110-HDRmHomology Directed RepairPuromycin0
(0)

Endothelin-3/EDN3/ET-3 Double Nickase Plasmid (m)

sc-420110-NICmGene KnockoutPuromycin0
(0)

Endothelin-3/EDN3/ET-3 Double Nickase Plasmid (m2)

sc-420110-NIC-2mGene KnockoutPuromycin0
(0)

Endothelin CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Endothelin-1/EDN1/ET-1 CRISPR Activation Plasmid (h)

sc-400564-ACThGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 CRISPR Activation Plasmid (h2)

sc-400564-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 Lentiviral Activation Particles (h)

sc-400564-LAChGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 Lentiviral Activation Particles (h2)

sc-400564-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 CRISPR Activation Plasmid (m)

sc-420108-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 CRISPR Activation Plasmid (m2)

sc-420108-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 Lentiviral Activation Particles (m)

sc-420108-LACmGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-1/EDN1/ET-1 Lentiviral Activation Particles (m2)

sc-420108-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 CRISPR Activation Plasmid (h)

sc-403871-ACThGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 CRISPR Activation Plasmid (h2)

sc-403871-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 Lentiviral Activation Particles (h)

sc-403871-LAChGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 Lentiviral Activation Particles (h2)

sc-403871-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 CRISPR Activation Plasmid (m)

sc-420109-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 CRISPR Activation Plasmid (m2)

sc-420109-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 Lentiviral Activation Particles (m)

sc-420109-LACmGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-2/EDN2/ET-2 Lentiviral Activation Particles (m2)

sc-420109-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 CRISPR Activation Plasmid (h)

sc-404436-ACThGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 CRISPR Activation Plasmid (h2)

sc-404436-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 Lentiviral Activation Particles (h)

sc-404436-LAChGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 Lentiviral Activation Particles (h2)

sc-404436-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 CRISPR Activation Plasmid (m)

sc-420110-ACTmGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 CRISPR Activation Plasmid (m2)

sc-420110-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 Lentiviral Activation Particles (m)

sc-420110-LACmGene ActivationPuro, Blast, Hygro0
(0)

Endothelin-3/EDN3/ET-3 Lentiviral Activation Particles (m2)

sc-420110-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

Endothelin siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Endothelin-1/EDN1/ET-1 siRNA (h)

sc-45394hGene SilencingN/A
5
(0)

Endothelin-1/EDN1/ET-1 shRNA Plasmid (h)

sc-45394-SHhGene SilencingPuromycin
5
(0)

Endothelin-1/EDN1/ET-1 shRNA (h) Lentiviral Particles

sc-45394-VhGene SilencingPuromycin
5
(0)

Endothelin-1/EDN1/ET-1 siRNA (m)

sc-45395mGene SilencingN/A
2
(0)

Endothelin-1/EDN1/ET-1 shRNA Plasmid (m)

sc-45395-SHmGene SilencingPuromycin
2
(0)

Endothelin-1/EDN1/ET-1 shRNA (m) Lentiviral Particles

sc-45395-VmGene SilencingPuromycin
2
(0)

Endothelin-1/EDN1/ET-1 siRNA (r)

sc-270091rGene SilencingN/A0
(0)

Endothelin-1/EDN1/ET-1 shRNA Plasmid (r)

sc-270091-SHrGene SilencingPuromycin0
(0)

Endothelin-1/EDN1/ET-1 shRNA (r) Lentiviral Particles

sc-270091-VrGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 siRNA (h)

sc-45396hGene SilencingN/A0
(0)

Endothelin-2/EDN2/ET-2 shRNA Plasmid (h)

sc-45396-SHhGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 shRNA (h) Lentiviral Particles

sc-45396-VhGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 siRNA (m)

sc-144951mGene SilencingN/A0
(0)

Endothelin-2/EDN2/ET-2 shRNA Plasmid (m)

sc-144951-SHmGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 shRNA (m) Lentiviral Particles

sc-144951-VmGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 siRNA (h)

sc-45397hGene SilencingN/A0
(0)

Endothelin-3/EDN3/ET-3 shRNA Plasmid (h)

sc-45397-SHhGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 shRNA (h) Lentiviral Particles

sc-45397-VhGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 siRNA (m)

sc-45398mGene SilencingN/A0
(0)

Endothelin-3/EDN3/ET-3 shRNA Plasmid (m)

sc-45398-SHmGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 shRNA (m) Lentiviral Particles

sc-45398-VmGene SilencingPuromycin0
(0)