Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Endothelins (ETs) exhibit strong constrictor activity over non-vascular and vascular smooth muscle. ETs can affect the central nervous system and neuronal excitability. The two receptor subtypes responsible for inducing vasoconstriction and vasodilation, ETA and ETB, are expressed in the lung, kidney, heart and liver. The genes encodeing human ET-1, 2 and 3 (EDN1, EDN2 and EDN3) map to chromosomes 6p23-p24, 1p34 and 20q13.2-q13.3, respectively. Of the three 21 amino acid isopeptides, ET-2 has the most potent vasoconstrictor activity. Biologically active ETs are proteolytically generated from a larger precursor, big-endothelin, by action of the endothelin-converting enzyme (ECE) family. ET-1 is a potent vasoconstrictor peptide produced by vascular endothelial cells. The ET-2 cDNA is 1.3 kb in length and encodes a proprotein consisting of 178 amino acid residues. ET-3 mRNA encodes a 230 amino acid precursor that includes ET-3 and a 15 amino acid homologous segment called the ET-3-like sequence. Pan ET antibodies provide detection for a range of endothelin proteins.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.