ENaC Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride hydrochloride dihydrate | 17440-83-4 | sc-364401 | 250 mg | $79.00 | 1 | |
Amiloride hydrochloride dihydrate functions as a selective inhibitor of epithelial sodium channels (ENaC), showcasing unique interactions with the channel's binding sites. Its structure facilitates strong electrostatic interactions and hydrogen bonding, which stabilize the inhibitor-channel complex. This specificity alters ion transport dynamics, influencing cellular sodium homeostasis. The compound's kinetic profile reveals a rapid onset of action, highlighting its potential to modulate ENaC activity effectively. | ||||||
Phenamil methanesulfonate salt | 2038-35-9 | sc-202280 | 5 mg | $108.00 | ||
Phenamil methanesulfonate salt acts as a potent modulator of epithelial sodium channels (ENaC), characterized by its ability to disrupt ion permeability through specific molecular interactions. Its unique sulfonate group enhances solubility and facilitates strong ionic interactions with channel residues, leading to conformational changes in ENaC. The compound exhibits distinct reaction kinetics, allowing for a nuanced regulation of sodium transport, thereby influencing cellular ion balance and signaling pathways. | ||||||
Triamterene-d5 | 396-01-0 unlabeled | sc-220323 | 5 mg | $330.00 | ||
Triamterene-d5 is a selective inhibitor of epithelial sodium channels (ENaC), distinguished by its deuterated structure that enhances stability and alters isotopic labeling in metabolic studies. Its unique molecular interactions involve hydrophobic and hydrogen bonding with channel proteins, promoting conformational shifts that modulate ion flow. The compound's kinetic profile reveals a rapid onset of action, allowing for precise control over sodium ion transport dynamics, impacting cellular homeostasis and signaling mechanisms. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $54.00 | ||
Triamterene acts as a potent modulator of epithelial sodium channels (ENaC), characterized by its ability to disrupt sodium ion reabsorption through specific binding interactions. Its unique structure facilitates strong hydrophobic interactions with the channel's lipid bilayer, influencing channel gating and permeability. The compound exhibits a distinctive kinetic behavior, with a notable affinity for the channel's open state, leading to altered ion transport rates and subsequent effects on cellular ionic balance and signaling pathways. | ||||||