Amiloride hydrochloride dihydrate CAS: 17440-83-4
MF: C6H8ClN7O•HCl•2H2O
MW: 302.12
An epithelial sodium channel blocker.

Amiloride hydrochloride dihydrate (CAS 17440-83-4)

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Alternate Names: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazine-carboxamide hydrochloride; Amiprazidine; Modamide
Application: Amiloride hydrochloride dihydrate is an epithelial sodium channel blocker
CAS Number: 17440-83-4
Molecular Weight: 302.12
Molecular Formula: C6H8ClN7O•HCl•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).

Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml, warm), DMSO (60 mg/ml at 25° C), and ethanol (< 1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
293.5° C
Refractive Index :
n20D ~1.88 (Predicted)
IC50 :
αENaC: IC50 = 776 nM (human); ENaC: IC50 = 0.2 µM (human); Sodium Channel Protein: IC50 = 1 µM; ASIC3: IC50 = 3.91 µM (human); uPA: IC50 = 11 µM (human)
Ki Data :
Adenosine A2A-R: Ki= 3.28 µM (human); SLC22A2: Ki= 4.7 µM (rat); OCT1: Ki= 6.9 µM (rat); uPA: Ki= 7 µM (human); Amine oxidase, copper containing: Ki= 10 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
68540
MDL Number :
MFCD00211292
Beilstein Registry :
4038903
SMILES :
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Amiloride hydrochloride dihydrate (CAS 17440-83-4)  Product Citations

See how others have used Amiloride hydrochloride dihydrate (CAS 17440-83-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22874502  Hsu, CY. et al. 2012. Biomaterials. 33: 7834-48.

Citations 1 to 1 of 1 total
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