Phenamil methanesulfonate salt (CAS 2038-35-9)

Phenamil methanesulfonate (free base) is a compound that functions as a sodium channel blocker. It acts by inhibiting the influx of sodium ions through voltage-gated sodium channels in cell membranes. This inhibition leads to a decrease in the excitability of cells, particularly in cardiac and neuronal tissues. By blocking sodium channels, it disrupts the generation and propagation of action potentials, thereby affecting the electrical activity of cells. Phenamil Methanesulfonate (Free Base)′s mechanism of action involves binding to specific sites on the sodium channels, altering their conformation and preventing the passage of sodium ions. As a result, it modulates the electrical signaling in cells, impacting their physiological functions. In experimental applications, Phenamil methanesulfonate (free base) is utilized to investigate the role of sodium channels in cellular excitability and to study the effects of sodium channel blockade on various physiological processes.