Ena1 Inhibitors

Ena1 inhibitors are chemicals that can modulate sodium homeostasis or inhibit ATPase functions, thus having an indirect effect on Ena1 protein's functionality. Ena1, a sodium ATPase, plays a crucial role in maintaining sodium balance within certain yeast cells. Agents like Digoxin and Ouabain, which belong to the cardiac glycoside family, inhibit ATPase activity. Their primary target is the Na+/K+ ATPase in cardiac cells, but given their mode of action, they can also inhibit proteins like Ena1 in yeasts. Furthermore, diuretics such as Amiloride, Triamterene, and Spironolactone, work by altering sodium homeostasis. By affecting sodium channels or sodium-potassium balance, these agents can indirectly affect the Ena1 protein.