Date published: 2025-10-15

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EMSY Inhibitors

EMSY inhibitors belong to a class of chemical compounds designed to impede the activity of EMSY, a protein associated with the regulation of gene expression and DNA repair processes. EMSY, short for BRCA2-interacting transcriptional repressor EMSY, serves as a critical component in cellular pathways that control the integrity and stability of the genome. Characterized by its involvement in DNA double-strand break repair mechanisms, EMSY is known to interact with key players in the DNA damage response, including the tumor suppressor protein BRCA2. The inhibition of EMSY through specific chemical agents aims to modulate these intricate cellular processes and disrupt the intricate network of interactions that govern DNA repair.EMSY inhibitors are designed to target the binding sites on the EMSY protein, disrupting its interaction with other cellular components. The development of these inhibitors often involves a thorough understanding of the three-dimensional structure of EMSY and the identification of key amino acid residues crucial for its function. Through rational drug design or high-throughput screening approaches, researchers aim to discover small molecules that can selectively bind to EMSY, inhibiting its biological activity.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is an inhibitor of PI3K, a kinase involved in the signaling pathway where EMSY is active. This compound can reduce the phosphorylation of proteins downstream of PI3K, indirectly affecting EMSY.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 also targets PI3K, reducing the activity of downstream proteins in the pathway that includes EMSY.

Erastin

571203-78-6sc-205677
sc-205677A
5 mg
50 mg
$365.00
$1582.00
1
(1)

Erastin is a small molecule that inhibits system Xc-, a cystine/glutamate antiporter. This can cause the buildup of reactive oxygen species (ROS), which can stress and potentially inhibit EMSY.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Staurosporine is a broad-spectrum protein kinase inhibitor and can affect the phosphorylation state of proteins in the pathway that EMSY is a part of.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is a tyrosine kinase inhibitor. EMSY, being a part of a signaling pathway, can be indirectly affected by changes in kinase activity.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 is a MEK inhibitor. Since MEK is in the pathway that involves EMSY, this compound can indirectly affect EMSY by altering the pathway.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is a JNK inhibitor. The JNK pathway intersects with the pathway involving EMSY, so inhibition of JNK can indirectly impact EMSY.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$182.00
$693.00
88
(1)

Y-27632 is a ROCK inhibitor. ROCK is involved in the signaling pathways that include EMSY, so its inhibition can indirectly affect EMSY.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a p38 MAPK inhibitor. The p38 MAPK pathway intersects with the pathway involving EMSY, so its inhibition can indirectly impact EMSY.

SU6656

330161-87-0sc-203286
sc-203286A
1 mg
5 mg
$56.00
$130.00
27
(1)

SU6656 is a Src family kinase inhibitor. The Src family kinases are involved in the signaling pathways that include EMSY, so its inhibition can indirectly affect EMSY.