Date published: 2025-10-22

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ELYS Inhibitors

Chemical inhibitors of ELYS can exert their effects through various non-transcriptional mechanisms that impact the protein's functionality within cellular processes. Importazole, for instance, is a small molecule that hinders the nuclear import receptor importin-β, which is essential for the nuclear import of ELYS. The disruption of importin-β by Importazole compromises ELYS's entry into the nucleus and its subsequent role in nuclear pore complex assembly. Similarly, Wortmannin operates by inhibiting phosphoinositide 3-kinases, which are integral to nuclear transport and other signaling pathways. By inhibiting this kinase, Wortmannin can indirectly influence ELYS by disrupting the necessary signaling for its nuclear-cytoplasmic trafficking. Leptomycin B, by inhibiting CRM1, leads to the accumulation of nuclear export signals containing proteins in the nucleus, possibly perturbing the function of ELYS due to the consequent alteration in nuclear transport dynamics.

Further influencing ELYS's function, Brefeldin A targets ADP-ribosylation factor, a key player in vesicle trafficking, potentially affecting ELYS indirectly by disrupting intracellular transport mechanisms. MLN4924's inhibition of the NEDD8 activating enzyme might interfere with proper NEDDylation of ELYS, thus affecting its function. Microtubule-affecting agents such as Monastrol, Nocodazole, Colchicine, Griseofulvin, and Vinblastine can also indirectly inhibit ELYS by altering the dynamics of microtubule-dependent processes, specifically those related to mitotic spindle formation that ELYS is known to be involved in. Monastrol, Nocodazole, Colchicine, Griseofulvin, and Vinblastine disrupt microtubule function, which can lead to an indirect inhibition of ELYS's role during mitosis. Ivermectin, although known for a different primary action involving chloride ion channels, can still indirectly affect ELYS function through potential downstream signaling effects resulting from the altered ionic balance it creates.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways, including those regulating nuclear transport. By inhibiting PI3K, wortmannin can indirectly affect the localization and function of ELYS, as PI3K activity is necessary for proper nuclear-cytoplasmic trafficking.

Leptomycin B

87081-35-4sc-358688
sc-358688A
sc-358688B
50 µg
500 µg
2.5 mg
$105.00
$408.00
$1224.00
35
(2)

Leptomycin B specifically inhibits exportin 1 (CRM1), which is responsible for nuclear export. While not directly inhibiting ELYS, by blocking CRM1, Leptomycin B can cause an accumulation of nuclear export signals (NES) containing proteins in the nucleus, potentially disrupting ELYS function due to altered nuclear transport dynamics.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), which is a small GTPase involved in the regulation of vesicle trafficking. Although ELYS is not directly involved in vesicle trafficking, the inhibition of ARF can lead to a disruption of overall intracellular transport processes, indirectly affecting ELYS function.

MLN 4924

905579-51-3sc-484814
1 mg
$280.00
1
(0)

MLN4924 is an inhibitor of NEDD8 activating enzyme (NAE), and since NEDDylation is a post-translational modification that can regulate protein function and localization, ELYS's function could be indirectly inhibited by preventing its proper NEDDylation through MLN4924's action.

Ivermectin

70288-86-7sc-203609
sc-203609A
100 mg
1 g
$56.00
$75.00
2
(2)

Ivermectin is an avermectin known to potentiate chloride ion flow through glutamate-gated channels. While its primary action is not on nuclear transport, the altered ionic balance and potential downstream signaling effects can indirectly influence ELYS's role in the nuclear pore complex.

Monastrol

254753-54-3sc-202710
sc-202710A
1 mg
5 mg
$120.00
$233.00
10
(1)

Monastrol is a kinesin Eg5 inhibitor, impairing spindle pole separation during mitosis. Considering that ELYS plays a role in mitotic spindle assembly through interactions with microtubules, Monastrol's effect on kinesin Eg5 can indirectly hinder ELYS's function in spindle formation.

Nocodazole

31430-18-9sc-3518B
sc-3518
sc-3518C
sc-3518A
5 mg
10 mg
25 mg
50 mg
$58.00
$83.00
$140.00
$242.00
38
(2)

Nocodazole disrupts microtubules and, consequently, can impact the mitotic spindle function. Given that ELYS is involved in mitotic spindle checkpoint function, the disruption of microtubule dynamics by Nocodazole can indirectly inhibit the function of ELYS.

Colchicine

64-86-8sc-203005
sc-203005A
sc-203005B
sc-203005C
sc-203005D
sc-203005E
1 g
5 g
50 g
100 g
500 g
1 kg
$98.00
$315.00
$2244.00
$4396.00
$17850.00
$34068.00
3
(2)

Colchicine binds to tubulin and prevents its polymerization, affecting microtubule assembly. Since ELYS is involved in chromatin decondensation and spindle assembly during mitosis, the inhibition of microtubule formation by Colchicine indirectly inhibits ELYS functionality.

Griseofulvin

126-07-8sc-202171A
sc-202171
sc-202171B
5 mg
25 mg
100 mg
$83.00
$216.00
$586.00
4
(2)

Griseofulvin disrupts microtubule function by binding to tubulin, impairing mitotic spindle formation. This can indirectly affect ELYS by disrupting its role in spindle checkpoint operations, as ELYS's function is closely tied to correct spindle assembly.

Vinblastine

865-21-4sc-491749
sc-491749A
sc-491749B
sc-491749C
sc-491749D
10 mg
50 mg
100 mg
500 mg
1 g
$100.00
$230.00
$450.00
$1715.00
$2900.00
4
(0)

Vinblastine binds to tubulin, inhibiting microtubule formation. As ELYS is essential for the proper functioning of the mitotic spindle, Vinblastine's impairment of microtubule polymerization can indirectly inhibit the function of ELYS.