ELYS Inhibitors
Chemical inhibitors of ELYS can exert their effects through various non-transcriptional mechanisms that impact the protein's functionality within cellular processes. Importazole, for instance, is a small molecule that hinders the nuclear import receptor importin-β, which is essential for the nuclear import of ELYS. The disruption of importin-β by Importazole compromises ELYS's entry into the nucleus and its subsequent role in nuclear pore complex assembly. Similarly, Wortmannin operates by inhibiting phosphoinositide 3-kinases, which are integral to nuclear transport and other signaling pathways. By inhibiting this kinase, Wortmannin can indirectly influence ELYS by disrupting the necessary signaling for its nuclear-cytoplasmic trafficking. Leptomycin B, by inhibiting CRM1, leads to the accumulation of nuclear export signals containing proteins in the nucleus, possibly perturbing the function of ELYS due to the consequent alteration in nuclear transport dynamics.
Further influencing ELYS's function, Brefeldin A targets ADP-ribosylation factor, a key player in vesicle trafficking, potentially affecting ELYS indirectly by disrupting intracellular transport mechanisms. MLN4924's inhibition of the NEDD8 activating enzyme might interfere with proper NEDDylation of ELYS, thus affecting its function. Microtubule-affecting agents such as Monastrol, Nocodazole, Colchicine, Griseofulvin, and Vinblastine can also indirectly inhibit ELYS by altering the dynamics of microtubule-dependent processes, specifically those related to mitotic spindle formation that ELYS is known to be involved in. Monastrol, Nocodazole, Colchicine, Griseofulvin, and Vinblastine disrupt microtubule function, which can lead to an indirect inhibition of ELYS's role during mitosis. Ivermectin, although known for a different primary action involving chloride ion channels, can still indirectly affect ELYS function through potential downstream signaling effects resulting from the altered ionic balance it creates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways, including those regulating nuclear transport. By inhibiting PI3K, wortmannin can indirectly affect the localization and function of ELYS, as PI3K activity is necessary for proper nuclear-cytoplasmic trafficking. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B specifically inhibits exportin 1 (CRM1), which is responsible for nuclear export. While not directly inhibiting ELYS, by blocking CRM1, Leptomycin B can cause an accumulation of nuclear export signals (NES) containing proteins in the nucleus, potentially disrupting ELYS function due to altered nuclear transport dynamics. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), which is a small GTPase involved in the regulation of vesicle trafficking. Although ELYS is not directly involved in vesicle trafficking, the inhibition of ARF can lead to a disruption of overall intracellular transport processes, indirectly affecting ELYS function. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is an inhibitor of NEDD8 activating enzyme (NAE), and since NEDDylation is a post-translational modification that can regulate protein function and localization, ELYS's function could be indirectly inhibited by preventing its proper NEDDylation through MLN4924's action. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin is an avermectin known to potentiate chloride ion flow through glutamate-gated channels. While its primary action is not on nuclear transport, the altered ionic balance and potential downstream signaling effects can indirectly influence ELYS's role in the nuclear pore complex. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor, impairing spindle pole separation during mitosis. Considering that ELYS plays a role in mitotic spindle assembly through interactions with microtubules, Monastrol's effect on kinesin Eg5 can indirectly hinder ELYS's function in spindle formation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules and, consequently, can impact the mitotic spindle function. Given that ELYS is involved in mitotic spindle checkpoint function, the disruption of microtubule dynamics by Nocodazole can indirectly inhibit the function of ELYS. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin and prevents its polymerization, affecting microtubule assembly. Since ELYS is involved in chromatin decondensation and spindle assembly during mitosis, the inhibition of microtubule formation by Colchicine indirectly inhibits ELYS functionality. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, impairing mitotic spindle formation. This can indirectly affect ELYS by disrupting its role in spindle checkpoint operations, as ELYS's function is closely tied to correct spindle assembly. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. As ELYS is essential for the proper functioning of the mitotic spindle, Vinblastine's impairment of microtubule polymerization can indirectly inhibit the function of ELYS. | ||||||