Elmo1 Inhibitors
Elmo1 inhibitors form a comprehensive arsenal of chemicals meticulously designed to precisely modulate the intricate activity of the Elmo1 protein. This diverse class of inhibitors extends its influence by targeting specific interacting partners or cellular pathways intricately associated with Elmo1, exemplifying the nuanced network through which Elmo1 function can be delicately regulated. Notable inhibitors like NSC23766 and EHop-016 direct their impact toward key players like Rac1, disrupting the Elmo1-Rac1 complex and consequently hindering Elmo1 activation. Additionally, compounds like AZA1 play an indirect yet pivotal role in influencing Elmo1 by disrupting ARF1 and Cdc42, underscoring the interconnected nature of GTPase-mediated pathways in the finely tuned regulation of Elmo1 function. The inhibition of RhoA by Y27632 or RhoA-specific inhibitors like Rhosin introduces yet another layer of complexity in the modulation of Elmo1, orchestrating alterations in cytoskeletal organization and cell motility. Furthermore, inhibitors targeting actin dynamics, such as LIMKi3 and Wiskostatin, indirectly shape Elmo1 activity by intricately affecting the actin cytoskeleton.
This multifaceted repertoire of inhibitors collectively highlights the sophisticated and strategic approaches employed to modulate Elmo1 function, providing profound insights into the elaborate regulatory mechanisms governing this protein's activity within the dynamic cellular context. As we delve deeper into the intricacies of Elmo1 modulation, these inhibitors not only serve as powerful tools in unraveling the fundamental biology of Elmo1 but also open new avenues for developing nuanced interventions. The precision exhibited by these inhibitors in targeting specific pathways and interacting partners underscores their ability in fine-tuning Elmo1 activity, thereby enriching our understanding of the multifaceted roles played by Elmo1 in various cellular processes. Collectively, these inhibitors exemplify the sophisticated strategies employed to delicately modulate Elmo1 function. Their precision in targeting specific pathways and interacting partners emphasizes the promise for nuanced interventions, offering a glimpse into the intricacies of Elmo1's regulatory mechanisms within the cellular landscape.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 is an inhibitor of the small GTPase ARF6, a regulator of membrane trafficking and a known binding partner of Elmo1. Inhibiting ARF6 with SecinH3 disrupts the interaction between ARF6 and Elmo1, thereby impeding the activation of Elmo1 and its participation in membrane dynamics and cellular protrusions. This interference highlights the intricate interplay between ARF6 and Elmo1 in cellular processes requiring dynamic membrane rearrangements. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
EHop-016 is a Rac GTPase inhibitor that selectively targets the GTP-bound active form of Rac1. By inhibiting Rac1 activation, EHop-016 disrupts the formation of the Elmo1-Rac1 complex, preventing Elmo1 activation and its downstream effects on cytoskeletal dynamics and cell motility. The specific interference with Rac1 activation demonstrates the precision with which Elmo1 function can be modulated through targeted inhibition of its interacting partners. | ||||||
AZA1 | 1071098-42-4 | sc-507497 | 10 mg | $600.00 | ||
AZA1 is a compound that interferes with Arf1, a small GTPase involved in vesicle trafficking and membrane dynamics. Given Elmo1's association with ARF6, AZA1 indirectly influences Elmo1 by disrupting Arf1-mediated cellular processes. This disruption can impact Elmo1 activation and its downstream signaling, underscoring the interconnected nature of GTPase-mediated pathways in regulating Elmo1 function within the cellular context. | ||||||
EMD 66684 | 187683-79-0 | sc-203941 sc-203941A | 10 mg 50 mg | $179.00 $760.00 | ||
EMD 66684 inhibits RhoA, a small GTPase involved in the regulation of cellular morphology and migration. Since RhoA interacts with Elmo1, inhibition of RhoA by EMD 66684 indirectly influences Elmo1 activity. This interference disrupts the intricate balance of signaling events involving Elmo1 and RhoA, leading to modifications in cellular processes such as cytoskeletal organization and cell motility that are orchestrated by the Elmo1-RhoA interplay. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of Cdc42, a Rho GTPase crucial for cell migration. By specifically targeting Cdc42, ML141 disrupts the interaction between Cdc42 and Elmo1, preventing the formation of the Elmo1-Rac1 complex. This disruption hampers Elmo1 activation and its subsequent involvement in cellular processes such as cytoskeleton reorganization and cell migration, providing a precise means of modulating Elmo1 function through the selective inhibition of its interacting partners. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y27632 is a Rho-associated protein kinase (ROCK) inhibitor that affects RhoA, a GTPase involved in cellular morphology and migration. Inhibition of ROCK by Y27632 indirectly influences Elmo1 activity through the disruption of RhoA-mediated signaling events. This interference alters the coordinated interplay between Elmo1 and RhoA, leading to modifications in cellular processes such as cytoskeletal organization and cell motility orchestrated by the Elmo1-RhoA axis. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin is a selective inhibitor of RhoA, a GTPase involved in the regulation of cellular morphology and migration. Inhibition of RhoA by Rhosin indirectly influences Elmo1 activity through the disruption of RhoA-mediated signaling events. This interference alters the coordinated interplay between Elmo1 and RhoA, leading to modifications in cellular processes such as cytoskeletal organization and cell motility orchestrated by the Elmo1-RhoA axis. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an N-WASP inhibitor that influences actin dynamics and cell motility. By inhibiting N-WASP, Wiskostatin indirectly modulates Elmo1 activity through its impact on the actin cytoskeleton. This interference disrupts the intricate balance of signaling events involving Elmo1 and actin dynamics, leading to modifications in cellular processes such as cell migration that are orchestrated by the interplay between Elmo1 and the actin cytoskeleton. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 is a Cdc42-specific inhibitor, targeting the GTP-bound active form of Cdc42. By inhibiting Cdc42 activation, ZCL278 disrupts the formation of the Elmo1-Rac1 complex, preventing Elmo1 activation and its downstream effects on cytoskeletal dynamics and cell motility. The specific interference with Cdc42 activation demonstrates the precision with which Elmo1 function can be modulated through targeted inhibition of its interacting partners. | ||||||