EHBP1 Inhibitors

EHBP1 inhibitors, as a chemical class, target diverse pathways and processes closely intertwined with the roles and functions of EHBP1, especially its involvement in endocytic trafficking and actin cytoskeleton dynamics. Key among these inhibitors are agents like Cytochalasin D and Latrunculin A, which modulate actin dynamics either by preventing polymerization or binding to actin monomers. Disruption or alterations in the actin cytoskeleton can significantly influence EHBP1's associated roles, given its close association with actin-mediated processes.

On the endocytic front, molecules like Dynasore act by inhibiting the GTPase activity of dynamin, crucial for vesicle scission during endocytosis. In tandem, PI3K inhibitors such as Wortmannin and LY294002 impede phosphoinositide signaling, a pivotal pathway for actin remodeling and vesicle formation. Other significant contributors like EHT 1864 and ML141 inhibit Rac1 GTPase, a central player in actin polymerization and endocytic activities.