EGFL3 Activators

EGFL3 activators are chemical compounds that enhance the function of EGFL3, a protein involved in several cellular processes, particularly the EGFR and ERK pathways. EGF, an activator of the EGFR pathway, enhances EGFL3 function by activating the EGFR pathway. PD 98059, U0126, sorafenib, regorafenib, selumetinib, trametinib, AZD6244, and cobimetinib are all inhibitors of components of the ERK pathway. Despite their inhibitory actions, these chemicals can enhance EGFL3 function by inducing a stress response in the ERK pathway, a pathway in which EGFL3 is involved.

Rather than enhancing its transcription or translation, or activating general pathways, these compounds directly or indirectly lead to the increased functional activity of EGFL3 through specific signaling pathways or biological processes that it is directly involved in. This intricate interaction of EGFL3 with other proteins and signaling pathways in the cell underscores the complexity and specificity of cellular functions and responses.