EG667292 Activators
Vomeronasal 1 receptor 111 activators are chemical compounds that interact with and enhance the activity of Vmn1r111. These activators include a variety of molecules like 2-heptanone and isoamyl acetate, which are small, volatile compounds known to be detected by vomeronasal receptors. These substances directly bind to Vmn1r111, triggering a cascade of intracellular events, primarily the release of calcium from intracellular stores, leading to the activation of the receptor and subsequent neuronal signaling. Additionally, neurosteroids such as pregnenolone sulfate modulate the sensitivity and responsiveness of Vmn1r111, thereby enhancing its signaling capabilities. This is critical for the accurate transmission of pheromonal information, which is essential for certain behavioral responses.
Other activators, such as putrescine and cadaverine, are biogenic amines that interact with vomeronasal receptors and can amplify signal transduction. The presence of these amines in the environment can enhance the functional activity of Vmn1r111, ensuring that the receptor is fully responsive to its ligands. On the steroidal front, compounds like androstenone and sulfated steroids serve as ligands for Vmn1r111, enhancing the receptor's activation and its downstream G-protein mediated signaling pathways. This elevated signaling is vital for the receptor to fulfill its role in detecting specific chemosensory cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone is a ketone known to be detected by vomeronasal receptors. Binding to Vmn1r111 can activate the receptor, leading to signal transduction through G-proteins and subsequent calcium signaling enhancement. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate is a compound with a banana-like odor, recognized by vomeronasal receptors. It can bind and activate Vmn1r111, enhancing intracellular calcium release and neuronal activation. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $99.00 | 2 | |
Pregnenolone sulfate is a neurosteroid that can potentiate signal transduction pathways by modulating receptor sensitivity, including vomeronasal receptors like Vmn1r111, enhancing its functional activity. | ||||||
Cadaverine | 462-94-2 | sc-239454 | 10 ml | $216.00 | ||
Cadaverine is a biogenic amine that binds vomeronasal receptors, potentially enhancing Vmn1r111 activation and leading to increased receptor-mediated signaling. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine, an alkaloid from black pepper, can enhance neurotransmitter release and may potentiate Vmn1r111 receptor signaling by increasing the availability of ligands for receptor activation. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin is an agonist that can stimulate TRPM8 receptors which are expressed in the vomeronasal system, thus potentially enhancing the overall sensitivity and response of Vmn1r111 to specific stimuli. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is integral to cell membrane structure and can modulate the physical environment of vomeronasal receptors like Vmn1r111, possibly enhancing ligand-receptor interactions. | ||||||
Dihydrocapsaicin | 19408-84-5 | sc-202578 sc-202578A | 10 mg 50 mg | $52.00 $156.00 | 1 | |
Dihydrocapsaicin, a capsaicinoid, can influence sensory neuron responses and may enhance Vmn1r111 receptor activity indirectly through modulation of the sensory system. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine is an amino acid that can modulate GABAergic and glycinergic neurotransmission, potentially influencing the activity of Vmn1r111 through indirect neuromodulatory effects. | ||||||