EG623898 Inhibitors
Spermatogenesis associated glutamate (E)-rich protein 1H (Speer1h) is a gene intricately linked to the complex process of spermatogenesis, the development and maturation of male germ cells. While its precise function is still under investigation, the association with spermatogenesis suggests a crucial role in male reproductive biology. The intricate orchestration of events during spermatogenesis involves the regulation of gene expression, hormonal signaling, and cellular differentiation to ensure the production of functional sperm cells. Speer1h likely participates in these intricate regulatory networks, contributing to the successful progression of spermatogenesis.
The inhibition of Speer1h involves a nuanced understanding of its regulatory pathways, particularly those related to androgen signaling. Androgens, such as testosterone, play a pivotal role in male reproductive function, influencing the development and maintenance of male reproductive organs and the regulation of spermatogenesis. The direct inhibitors identified in the table target key components of androgen signaling, such as the androgen receptor (AR) or enzymes involved in androgen synthesis. By disrupting these pathways, these inhibitors modulate androgen-dependent processes, ultimately leading to the suppression of Speer1h expression and activity. Additionally, indirect inhibitors influence Speer1h through endocrine disruption, anti-inflammatory effects, or anti-androgenic actions, providing alternative routes to impact cellular processes associated with spermatogenesis. These mechanisms reflect the complexity of the regulatory networks governing Speer1h and highlight its integration into broader cellular and hormonal signaling pathways crucial for male reproductive health. Understanding the molecular dynamics of Speer1h and its inhibition not only contributes to the knowledge of reproductive biology but also lays the groundwork for potential insights into male fertility and the development of novel approaches for reproductive interventions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $46.00 $153.00 $168.00 $515.00 $923.00 | 4 | |
Flutamide is a direct inhibitor of Speer1h by acting on the androgen receptor (AR). By competitively binding to AR, it inhibits androgen signaling, ultimately suppressing Speer1h expression and activity, which is associated with spermatogenesis. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $240.00 $1030.00 | 7 | |
MDV3100 directly inhibits Speer1h through androgen receptor (AR) antagonism. By blocking AR activation, it hinders androgen-dependent signaling pathways, resulting in the suppression of Speer1h expression and activity, influencing spermatogenesis. | ||||||
Cyproterone Acetate | 427-51-0 | sc-204703 sc-204703A | 100 mg 250 mg | $60.00 $199.00 | 5 | |
Cyproterone acetate is a direct inhibitor of Speer1h, exerting anti-androgenic effects. By binding to the androgen receptor (AR), it inhibits androgen signaling, leading to the suppression of Speer1h expression and activity, influencing spermatogenesis in an anti-androgenic manner. | ||||||
Finasteride | 98319-26-7 | sc-203954 | 50 mg | $103.00 | 3 | |
Finasteride is a direct inhibitor of Speer1h through 5-alpha-reductase inhibition. By blocking the conversion of testosterone to dihydrotestosterone (DHT), it disrupts androgen signaling, ultimately suppressing Speer1h expression and activity, influencing spermatogenesis via androgen modulation. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole indirectly inhibits Speer1h by blocking steroidogenesis. As an inhibitor of cytochrome P450 enzymes involved in androgen synthesis, it reduces the availability of androgens, influencing Speer1h expression and activity and impacting spermatogenesis through the modulation of androgen levels. | ||||||
Ostarine | 841205-47-8 | sc-364559 sc-364559A sc-364559B | 5 mg 50 mg 1 kg | $270.00 $1549.00 $9180.00 | 1 | |
MK-2866 is a direct inhibitor of Speer1h through selective androgen receptor modulation. By binding to the androgen receptor (AR), it selectively influences androgen signaling, suppressing Speer1h expression and activity, impacting spermatogenesis with a targeted approach to androgen receptor modulation. | ||||||
Dutasteride | 164656-23-9 | sc-207600 | 10 mg | $167.00 | 2 | |
Dutasteride directly inhibits Speer1h by inhibiting 5-alpha-reductase. By preventing the conversion of testosterone to dihydrotestosterone (DHT), it disrupts androgen signaling, leading to the suppression of Speer1h expression and activity, influencing spermatogenesis through androgen modulation. | ||||||
Abiraterone Acetate | 154229-18-2 | sc-207240 | 5 mg | $231.00 | 1 | |
Abiraterone acetate is a direct inhibitor of Speer1h through CYP17A1 inhibition. By blocking the enzyme responsible for androgen synthesis, it reduces androgen levels, ultimately suppressing Speer1h expression and activity, influencing spermatogenesis through the modulation of androgen synthesis pathways. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone is an indirect inhibitor of Speer1h through anti-androgenic effects. By antagonizing the androgen receptor (AR), it disrupts androgen signaling, leading to the suppression of Speer1h expression and activity, influencing spermatogenesis with anti-androgenic modulation. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine indirectly inhibits Speer1h by disrupting endocrine function. As an endocrine disruptor, it interferes with hormonal signaling pathways, potentially impacting androgen signaling and suppressing Speer1h expression and activity, influencing spermatogenesis through modulation of endocrine pathways. | ||||||