EG243302 Activators

Gm4963, a predicted gene with functional characteristics akin to IFI16, stands as a pivotal orchestrator in cellular processes governing gene expression and the regulation of the innate immune response. With attributed DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding activity, and identical protein binding activity, Gm4963 is primarily localized within the nucleolus and nucleoplasm. Its multifaceted role is evident in the regulation of cysteine-type endopeptidase activity and the innate immune response, underscoring its significance in maintaining cellular homeostasis. The activation of Gm4963 involves intricate signaling pathways influenced by specific biochemical modulators. These activators impact Gm4963 directly or indirectly, emphasizing the diverse mechanisms by which this gene is regulated. Various compounds, acting through different signaling pathways, contribute to the up-regulation, stimulation, enhancement, and promotion of Gm4963. For instance, the activation of Gm4963 through the SIRT1/AMPK pathway by Resveratrol highlights its involvement in DNA binding and nucleolar functions. Modulation of NF-κB signaling by Quercetin showcases the intricate crosstalk between Gm4963 and innate immune responses within the nucleoplasm.

Moreover, Gm4963 activation is influenced by compounds such as Ursolic Acid through the mTOR pathway, emphasizing its role in RNA polymerase II-specific DNA binding and gene expression regulation. Triggering Gm4963 through TLR4 signaling by Curcumin elucidates its impact on cysteine-type endopeptidase activity and innate immune responses. The activation via the JNK signaling pathway by Carnosic Acid further emphasizes Gm4963's involvement in identical protein binding and nucleolus-associated functions. These diverse pathways collectively contribute to the intricate regulation of Gm4963, highlighting its central role in cellular homeostasis and the modulation of key cellular activities.