EAN57 Activators
Cilia are slender, hair-like projections on the surface of many eukaryotic cells. They are classified as either motile or non-motile (primary cilia) and play critical roles in cell locomotion, fluid movement, sensing environmental cues, and signal transduction. The core structural component of a cilium is the axoneme, which typically consists of a ring of nine outer microtubule doublets surrounding a central pair of microtubules, known as the "9+2" arrangement in motile cilia. Primary cilia usually lack the central pair, resulting in a "9+0" structure.
Ciliary microtubules are stabilized and supported by various proteins, including inner arm dyneins, radial spokes, and nexin links, as well as numerous microtubule-associated proteins (MAPs). These components are essential for the proper assembly and function of the axoneme. Defects in the proteins associated with the ciliary microtubules can result in ciliopathies, a group of disorders that include diseases such as polycystic kidney disease, Bardet-Biedl syndrome, and primary ciliary dyskinesia.The term "inner protein" implies a location within the ciliary structure, potentially interacting directly with the microtubules to influence their stability, organization, or dynamic properties.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
By stabilizing microtubules, Paclitaxel enhances their polymerization, potentially supporting the function of ciliary microtubule inner protein 4 by maintaining microtubule integrity within cilia. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules but can lead to compensatory mechanisms that enhance microtubule stability, possibly involving the activation of ciliary microtubule inner protein 4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which could activate PKA. PKA phosphorylation can modulate microtubule-associated proteins, potentially enhancing the activity of ciliary microtubule inner protein 4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can inhibit GSK-3, leading to increased stability of microtubule structures, which could indirectly enhance the activity of ciliary microtubule inner protein 4 through stabilization. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several kinases and could alter microtubule dynamics, potentially upregulating ciliary microtubule inner protein 4 function in response to altered signaling. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
While Vinblastine disrupts microtubules, cells may compensate by activating proteins that stabilize microtubules, such as ciliary microtubule inner protein 4, to maintain ciliary function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule polymerization, which could trigger a cellular response that activates microtubule-stabilizing proteins like ciliary microtubule inner protein 4. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Despite being an actin polymerization inhibitor, Cytochalasin D could indirectly affect microtubule dynamics, potentially enhancing ciliary microtubule inner protein 4 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects various signaling pathways and could indirectly influence microtubule stability, potentially enhancing the activity of ciliary microtubule inner protein 4. | ||||||