E430025E21Rik Inhibitors
Chemical inhibitors of E430025E21Rik can impede its function in various ways, each targeting a different aspect of the protein's role in endosomal sorting and trafficking. Filastatin, for instance, non-competitively inhibits fungal adhesins, which could be analogous to the inhibition of E430025E21Rik's function in cell adhesion processes. Since E430025E21Rik is involved with the endosomal pathway, the interference with adhesins can disrupt the protein's ability to manage vesicular sorting. Dynasore, on the other hand, hinders the GTPase activity of dynamin, which is crucial for vesicle scission during clathrin-mediated endocytosis, a pathway where E430025E21Rik is implicated. The inhibition of dynamin activity by Dynasore can therefore prevent the proper functioning of E430025E21Rik in endocytic recycling.
Similarly, Cytochalasin D disrupts actin filaments, thereby potentially altering the cytoskeletal dynamics essential for E430025E21Rik's role in vesicular transport. Pitstop 2 targets the interaction between clathrin and adaptor proteins, disrupting clathrin-mediated endocytosis, which can affect the sorting of cargo proteins within vesicles, a process E430025E21Rik is involved with. Endosidin1 interferes with the ESCRT machinery, essential for multivesicular body formation, thus likely affecting the E430025E21Rik-related sorting pathways. ML141 selectively inhibits Cdc42 GTPase, and by doing so, can hinder cytoskeletal rearrangements that are necessary for vesicular transport and sorting functions of E430025E21Rik. Exo2 targets the assembly of the exocyst complex, which is crucial for vesicle tethering and fusion during exocytosis, processes that are within E430025E21Rik's functional repertoire. Ikarugamycin inhibits the formation of clathrin-coated vesicles, and thus can impede E430025E21Rik's function in endocytic recycling and sorting of transmembrane proteins. MiTMAB's inhibition of dynamin II affects vesicle scission, which is a step in endocytosis where E430025E21Rik may have a role. Lastly, SecinH3 inhibits cytohesin, thereby potentially disrupting the activation of small G proteins involved in intracellular signaling and vesicle trafficking, which can affect the transport processes regulated by E430025E21Rik. Tyrphostin A23's inhibition of endocytic vesicle assembly further contributes to the range of mechanisms by which E430025E21Rik's function in vesicular trafficking can be inhibited.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore acts as an inhibitor of the GTPase activity of dynamin, which is essential for clathrin-mediated endocytosis. Since E430025E21Rik has a role in vesicular trafficking, Dynasore's action can impede the recycling of vesicles, thus functionally inhibiting the endosomal sorting processes where E430025E21Rik is involved. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization, which is crucial for maintaining cell shape and enabling various cellular processes including vesicle movement. By interfering with cytoskeletal dynamics, Cytochalasin D can inhibit the vesicular transport functions in which E430025E21Rik is implicated. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis by blocking the interaction between clathrin and adaptor proteins. E430025E21Rik's function in endosomal sorting could be inhibited by Pitstop 2 as it would disrupt the internalization and routing of cargo proteins that E430025E21Rik is likely to be involved with. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a selective inhibitor of Cdc42 GTPase. E430025E21Rik, which is involved in vesicular transport and endosomal sorting that can be regulated by the actin cytoskeleton, would be functionally inhibited by ML141 as it would prevent the proper regulation of the cytoskeletal rearrangements required for these processes. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $87.00 $282.00 | 1 | |
Exo2 selectively inhibits exocyst complex assembly, which is essential for vesicle tethering during exocytosis. E430025E21Rik's role in vesicular trafficking could be inhibited by Exo2, as it would disrupt vesicle delivery and membrane fusion events that E430025E21Rik may regulate. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $185.00 | 4 | |
Ikarugamycin inhibits clathrin-dependent endocytosis by affecting the clathrin-coated vesicle formation. The inhibition of this pathway can functionally inhibit E430025E21Rik by preventing the endocytic recycling and sorting of transmembrane proteins, a process that E430025E21Rik is likely involved in. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
SecinH3 inhibits cytohesin, a family of GDP-GTP exchange factors for small G proteins, which are involved in intracellular signaling and vesicle trafficking. E430025E21Rik, which has a role in vesicular transport, would be inhibited by SecinH3 as it would disrupt the activation of small G proteins that facilitate this transport. | ||||||
Tyrphostin A23 | 118409-57-7 | sc-3554 | 10 mg | $110.00 | 13 | |
Tyrphostin A23 is an inhibitor of tyrosine kinase activity and also blocks endocytosis by inhibiting the assembly of endocytic vesicles. Since E430025E21Rik is associated with endosomal sorting and vesicle formation, Tyrphostin A23 can functionally inhibit E430025E21Rik. | ||||||