DRAM Activators
DRAM activators represent a diverse class of chemicals that exert their effects on the protein DRAM (DNA damage-regulated autophagy modulator 1). DRAM plays a crucial role in autophagy, a cellular process involved in the degradation and recycling of cellular components. The selected chemicals, including Rapamycin, Torin 1, Resveratrol, Chloroquine, Spautin-1, SBI-0206965, Lithium Chloride, SB216763, Niclosamide, NSC 67078, LY294002, and Cisplatin, directly enhance the functional activity of DRAM through various mechanisms. Rapamycin and Torin 1 act as mTOR inhibitors, relieving mTORC1 suppression on DRAM expression and promoting autophagy. Resveratrol activates AMPK signaling, leading to increased DRAM expression and autophagy initiation. Chloroquine inhibits lysosomal function, stabilizing DRAM and enhancing autophagy. Spautin-1 inhibits USP10 and USP13, preventing ubiquitin-mediated degradation of DRAM. SBI-0206965, an AMPK inhibitor, suppresses AMPK signaling, leading to decreased DRAM expression and autophagy induction.
Lithium Chloride and SB216763 target GSK-3β, stabilizing DRAM and initiating autophagy. Niclosamide activates AMPK signaling, promoting DRAM-mediated autophagy. NSC 67078, a p53 inhibitor, prevents p53-mediated repression of DRAM, enhancing autophagy. LY294002 inhibits PI3K/AKT signaling, suppressing autophagic responses mediated by DRAM. Cisplatin induces DNA damage and activates the p53 pathway, leading to increased DRAM expression and autophagy initiation. These DRAM activators provide valuable tools for understanding and manipulating autophagic processes, offering insights into the intricate regulation of cellular homeostasis. The diversity of mechanisms employed by these chemicals highlights the complexity of autophagy regulation and the multifaceted role of DRAM in maintaining cellular balance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, also known as Sirolimus, directly enhances the functional activity of DRAM by activating the mTOR pathway. It inhibits mTORC1, relieving its suppressive effect on DRAM expression. Consequently, Rapamycin induces autophagy through DRAM upregulation, leading to increased lysosomal degradation and cellular recycling. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1, a potent mTOR inhibitor, enhances DRAM functional activity by suppressing mTORC1 and mTORC2 activities. Through its inhibitory effect on mTOR, Torin 1 activates autophagy by upregulating DRAM expression. This direct activation occurs via the inhibition of mTOR-dependent signaling pathways, promoting autophagic processes that enhance DRAM-mediated cellular degradation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, directly enhances DRAM functional activity by activating the AMPK signaling pathway. It induces AMPK phosphorylation, leading to increased DRAM expression and subsequent autophagy initiation. This direct activation occurs through the modulation of AMPK-dependent signaling pathways, positioning Resveratrol as a specific enhancer of DRAM functional activity by promoting autophagic responses. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine directly enhances DRAM functional activity by inhibiting lysosomal function. It impairs lysosomal acidification, leading to the stabilization of DRAM protein and increased autophagy. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 directly enhances DRAM functional activity by inhibiting USP10 and USP13, leading to increased DRAM stability and autophagy induction. This direct activation occurs through the modulation of deubiquitination processes, positioning Spautin-1 as a specific enhancer of DRAM functional activity by preventing ubiquitin-mediated degradation. | ||||||
SBI-0206965 | 1884220-36-3 | sc-507431 | 10 mg | $124.00 | ||
SBI-0206965, an AMPK inhibitor, enhances DRAM functional activity by inhibiting AMPK signaling. Its inhibitory effect on AMPK leads to decreased DRAM expression and autophagy induction. This direct activation occurs through the modulation of AMPK-dependent signaling pathways, positioning SBI-0206965 as a specific enhancer of DRAM functional activity by suppressing autophagic responses. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride directly enhances DRAM functional activity by inhibiting GSK-3β, leading to increased DRAM stability and autophagy initiation. This direct activation occurs through the modulation of GSK-3β-dependent signaling pathways, positioning Lithium Chloride as a specific enhancer of DRAM functional activity by preventing GSK-3β-mediated degradation. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763, a GSK-3β inhibitor, directly enhances DRAM functional activity by suppressing GSK-3β activity. Its inhibitory effect on GSK-3β leads to increased DRAM expression and autophagy initiation. This direct activation occurs through the modulation of GSK-3β-dependent signaling pathways, positioning SB216763 as a specific enhancer of DRAM functional activity by preventing GSK-3β-mediated degradation. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide directly enhances DRAM functional activity by activating AMPK signaling. It induces AMPK phosphorylation, leading to increased DRAM expression and autophagy initiation. This direct activation occurs through the modulation of AMPK-dependent signaling pathways, positioning Niclosamide as a specific enhancer of DRAM functional activity by promoting autophagic responses. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $180.00 $651.00 | ||
PKF118-310, a p53 inhibitor, directly enhances DRAM functional activity by suppressing p53-dependent repression. Its inhibitory effect on p53 leads to increased DRAM expression and autophagy initiation. | ||||||