DPRP Activators
Prl8a2, a member of the prolactin family, plays a pivotal role in hormone activity and prolactin receptor binding. This gene is actively expressed in crucial tissues such as the branchial arch, extraembryonic components, and placenta, contributing to maternal processes during female pregnancy and responses to hypoxia. The gene's human ortholog, PRL (prolactin), implicates it in carotid artery disease. Activation of Prl8a2 involves a complex interplay of various chemicals targeting specific cellular pathways.
Direct activators like Retinoic Acid, 9-cis-Retinoic Acid, and Dibutyryl cAMP directly engage pathways associated with retinoic acid receptors and cAMP-dependent cascades, enhancing gene expression linked to hormone activity. Indirect activators, including Sodium Butyrate and Trichostatin A, modulate Prl8a2 via epigenetic mechanisms by inhibiting histone deacetylases, promoting histone acetylation, and positively influencing gene transcription. Furthermore, chemicals like 5-Azacytidine and Valproic Acid impact DNA methylation patterns, indirectly up-regulating Prl8a2 by demethylating associated gene regions. The unique actions of each chemical contribute to the overall activation of Prl8a2, providing potential avenues for influencing its functions in physiological contexts. Understanding these activation mechanisms enhances our grasp of the gene's role and opens avenues for targeted modulation in various biological processes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid stimulates the prolactin receptor binding activity of Prl8a2. It activates cellular pathways involving retinoic acid receptors, modulating gene expression crucial for the hormone activity. Through these actions, Retinoic Acid enhances the up-regulation of Prl8a2, influencing maternal processes during female pregnancy and responses to hypoxia. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly up-regulates Prl8a2 by activating adenylate cyclase and increasing intracellular cAMP levels. Elevated cAMP promotes hormonal activities of Prl8a2 and enhances its binding to prolactin receptors. The compound engages cAMP-dependent pathways, triggering the expression of Prl8a2 in tissues like the branchial arch, extraembryonic components, and placenta, playing a vital role in cellular responses. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
9-cis-Retinoic Acid acts as a direct activator, influencing Prl8a2 by engaging retinoic acid receptors. This chemical modulates the gene expression associated with hormone activity, positively regulating the prolactin receptor binding of Prl8a2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate indirectly activates Prl8a2 by inhibiting histone deacetylases. Through epigenetic modifications, it enhances the transcription of Prl8a2-associated genes, contributing to increased hormone activity. The compound stimulates cellular processes involved in female pregnancy and response to hypoxia, providing a unique avenue for promoting Prl8a2 function through histone acetylation mechanisms. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly activates Prl8a2 by promoting histone acetylation. This epigenetic modulation enhances the transcription of genes related to hormone activity, positively impacting Prl8a2 function. The compound plays a role in up-regulating Prl8a2, influencing maternal processes during female pregnancy and responses to hypoxia, thereby contributing to the protein's functional enhancement. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine acts as an indirect activator by inhibiting DNA methyltransferases. This epigenetic modulation positively impacts Prl8a2 expression by demethylating associated gene regions. The compound contributes to the up-regulation of Prl8a2, affecting hormone activity and prolactin receptor binding, with implications in maternal processes during female pregnancy and responses to hypoxia. The demethylation process indirectly supports Prl8a2 activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP directly activates Prl8a2 by mimicking the intracellular actions of cAMP. This chemical up-regulates Prl8a2 by engaging cAMP-dependent pathways, promoting hormone activity and enhancing prolactin receptor binding. Its impact extends to maternal processes during female pregnancy and responses to hypoxia, offering a direct avenue for activating Prl8a2 through the manipulation of cAMP signaling cascades. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyric Acid, through its histone deacetylase inhibitory activity, indirectly activates Prl8a2 by promoting histone acetylation. This epigenetic modulation enhances the transcription of genes associated with hormone activity, positively impacting Prl8a2 function. The compound contributes to up-regulating Prl8a2, influencing maternal processes during female pregnancy and responses to hypoxia, offering a unique avenue for functional enhancement. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, indirectly activates Prl8a2 by promoting histone acetylation. This epigenetic modulation positively impacts the transcription of genes associated with hormone activity, enhancing Prl8a2 function. The compound contributes to the up-regulation of Prl8a2, influencing maternal processes during female pregnancy and responses to hypoxia, providing a distinct pathway for functional activation. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
Sodium Phenylbutyrate indirectly activates Prl8a2 by inhibiting histone deacetylases. Through epigenetic modifications, it enhances the transcription of Prl8a2-associated genes, contributing to increased hormone activity. The compound stimulates cellular processes involved in female pregnancy and response to hypoxia, providing a unique avenue for promoting Prl8a2 function through histone acetylation mechanisms. | ||||||