DP2_CRTH2 Activators

DP2_CRTH2 activators include a range of chemicals that directly activate the CRTH2 receptor or modulate its activity through various pathways related to prostaglandin metabolism. CRTH2, primarily activated by Prostaglandin D2 (PGD2), plays a crucial role in mediating inflammatory and allergic responses, particularly in Th2 cells. Direct activators such as Prostaglandin D2 and BW245C bind specifically to the CRTH2 receptor, mimicking or enhancing its natural ligand's effect. BW245C, a selective agonist, is particularly notable for its ability to closely replicate the action of PGD2 on CRTH2. Indirect activators like 15-deoxy-Δ12,14-prostaglandin J2 and Prostaglandin D1, though less potent, contribute to CRTH2 activation by interacting with the PGD2 pathway or through partial agonistic effects.

The role of arachidonic acid as a precursor to PGD2 underscores the importance of upstream elements in CRTH2 activation. Chemicals like Selexipag, Misoprostol, and Carbaprost, while not directly interacting with CRTH2, influence its activity by modulating prostaglandin metabolism. This indirect regulation illustrates the interconnected nature of prostaglandin pathways. Additionally, compounds such as Indomethacin, Aspirin, and Celecoxib, known for their roles in cyclooxygenase inhibition, indirectly affect CRTH2 by altering the synthesis of prostaglandins. These interactions highlight the complex regulatory networks governing inflammatory responses and the potential for various compounds to influence CRTH2 activity, both directly and indirectly.