Date published: 2025-11-2

1-800-457-3801

SCBT Portrait Logo
Seach Input

DP Activators

DP activators comprise a group of chemicals designed to modulate the function of the DP protein, which generally refers to one of the two proteins, DP1 or DP2, that pair with E2F transcription factors to form heterodimers. These heterodimers are crucial for the regulation of the cell cycle, particularly the transition from the G1 to the S phase, where cellular DNA is replicated. DP-E2F complexes play a pivotal role in controlling the expression of genes that are required for DNA synthesis and cell cycle progression. Direct activators of DP proteins would typically bind to either DP1 or DP2 and increase their ability to form active complexes with E2F proteins. This activation could involve an allosteric change in the DP protein structure that enhances its affinity for E2F or facilitates nuclear localization where it can exert its effects on gene transcription. Alternatively, a direct activator might mimic the interaction of DP with E2F, promoting the transcriptional activity of E2F on target genes. Indirect activators could function by several mechanisms, such as upregulating the expression of the DP proteins, thereby increasing the pool of available DP for complex formation. They might also influence the post-translational modifications of DP proteins that are critical for their function, such as phosphorylation, which often regulates protein-protein interactions and DNA binding. Furthermore, indirect activators could act by inhibiting the proteins that sequester DP or E2F in the cytoplasm, thus promoting their translocation to the nucleus and enhancing their transcriptional activity.

SEE ALSO...

Items 1 to 10 of 13 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PGD2 (Prostaglandin D2)

41598-07-6sc-201221
sc-201221A
1 mg
10 mg
$94.00
$572.00
4
(1)

Prostaglandin D2 (PGD2) acts as a potent signaling molecule, primarily engaging with the DP receptor to modulate various physiological responses. Its unique structure allows for specific hydrogen bonding and hydrophobic interactions, influencing downstream signaling cascades. PGD2's rapid synthesis and degradation highlight its role in dynamic cellular environments, while its ability to form stable complexes with proteins enhances its regulatory functions in diverse biological processes.

BW 245C

72814-32-5sc-205230
sc-205230A
1 mg
5 mg
$103.00
$370.00
(0)

BW 245C is a selective agonist that interacts with the DP receptor, exhibiting unique binding characteristics that facilitate specific conformational changes in the receptor structure. This compound demonstrates distinct kinetic profiles, influencing receptor activation and downstream signaling pathways. Its lipophilic nature enhances membrane permeability, allowing for efficient cellular uptake and interaction with lipid bilayers, which may affect its distribution and bioavailability in various environments.

BAY-u 3405

116649-85-5sc-203834
sc-203834A
10 mg
50 mg
$189.00
$797.00
(0)

Ramatroban is a dual DP and TP receptor antagonist. However, in the presence of high concentrations of PGD2, it could serve to increase the availability of PGD2 for DP, thus indirectly enhancing DP′s functional activity.

Sulprostone

60325-46-4sc-201348
sc-201348A
1 mg
5 mg
$206.00
$592.00
8
(1)

Sulprostone is a synthetic prostaglandin E2 analog. It can potentially enhance DP activity by increasing the synthesis and release of PGD2, a major DP ligand, through modulation of the prostaglandin synthesis pathway.

Beraprost sodium salt

88475-69-8sc-204644
sc-204644A
1 mg
5 mg
$214.00
$970.00
(0)

Beraprost Sodium is a synthetic analog of prostacyclin (PGI2). It can indirectly enhance DP activation by increasing the synthesis and release of PGD2, a primary DP ligand.

Aspirin

50-78-2sc-202471
sc-202471A
5 g
50 g
$20.00
$41.00
4
(1)

Aspirin inhibits COX-1 and COX-2 enzymes, reducing the production of other prostaglandins. This could increase the availability of PGD2 for DP, which could in turn enhance DP's functional activity.

Misoprostol

59122-46-2sc-201264
sc-201264A
sc-201264B
10 mg
100 mg
1 g
$179.00
$1126.00
$6941.00
2
(1)

Misoprostol is a synthetic PGE1 analog. It can potentially enhance DP activity by increasing the synthesis and release of PGD2, a major DP ligand, through modulation of the prostaglandin synthesis pathway.

Latanoprost

130209-82-4sc-201354
sc-201354A
sc-201354A-CW
1 mg
5 mg
5 mg
$58.00
$230.00
$306.00
2
(1)

Latanoprost is a prostaglandin F2α analog. It can potentially enhance DP activity by increasing the synthesis and release of PGD2, a major DP ligand, through modulation of the prostaglandin synthesis pathway.

PGE1 (Prostaglandin E1)

745-65-3sc-201223
sc-201223A
1 mg
10 mg
$30.00
$142.00
16
(4)

Alprostadil is a synthetic prostaglandin E1. It could enhance DP activity by increasing the synthesis and release of PGD2, a major ligand for DP, through modulation of the prostaglandin synthesis pathway.

Fluprostenol isopropyl ester

157283-68-6sc-205327
sc-205327A
1 mg
5 mg
$80.00
$465.00
(0)

Travoprost is a synthetic analog of prostaglandin F2α. It can potentially enhance DP activity by increasing the synthesis and release of PGD2, a major DP ligand, through modulation of the prostaglandin synthesis pathway.