DNAHC7B Activators
DNAHC7B, short for Dynein Axonemal Heavy Chain 7B, is a gene that encodes a vital component of the dynein motor protein complex within the cilia and flagella of cells. The protein product of this gene plays a crucial role in the movement and function of these cellular structures, which are essential for a variety of biological processes including cellular motility, signaling, and the proper flow of fluids across cellular surfaces. The expression of DNAHC7B is intricately controlled by a myriad of cellular mechanisms, ensuring that it is synthesized in the right place and at the appropriate times. Understanding how to upregulate the expression of DNAHC7B can provide insights into the fundamental aspects of cell biology and the maintenance of cellular health.
Research into the molecular biology of gene expression has identified several chemicals that can serve as activators to increase the expression of genes like DNAHC7B. Such activators may work at a genetic level, influencing the transcriptional machinery directly, or they might exert their effects indirectly by modulating the signaling pathways that govern gene expression. For instance, certain compounds can enhance transcription by altering the epigenetic landscape of the DNAHC7B gene, making it more accessible to the transcriptional machinery. Other substances might stimulate signaling cascades that result in the phosphorylation and activation of transcription factors, which then bind to the promoter regions of target genes like DNAHC7B, initiating the transcription process. These activators are of high interest in the field of molecular genetics, as they shed light on the dynamic nature of gene expression and the possibility of modulating it through external means. Understanding these interactions is a key area of research that continues to expand our knowledge of genetic expression and cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could upregulate DNAHC7B expression by activating retinoic acid receptors that bind to retinoic acid response elements in the promoter region of the DNAHC7B gene, initiating transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inducing demethylation of cytosine bases within CpG islands of the DNAHC7B promoter, 5-Azacytidine may stimulate the transcriptional activation of the gene, leading to increased mRNA synthesis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could stimulate DNAHC7B expression by elevating intracellular cAMP levels, thereby activating the cAMP-dependent protein kinase A (PKA), which may phosphorylate transcription factors that enhance DNAHC7B gene transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride might induce DNAHC7B expression by inhibiting GSK-3β, resulting in the activation of the Wnt signaling pathway and subsequent stabilization and nuclear translocation of β-catenin, which may bind to and activate DNAHC7B gene promoters. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could upregulate DNAHC7B through binding to estrogen receptors that interact with estrogen response elements upstream of the DNAHC7B gene, enhancing the recruitment of coactivators required for transcription initiation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate may increase DNAHC7B expression by inhibiting histone deacetylases, leading to hyperacetylation of histones associated with the DNAHC7B gene promoter, and thereby facilitating the assembly of the transcriptional machinery. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate may stimulate DNAHC7B expression by activating upstream kinases that phosphorylate transcription factors, leading to their enhanced binding and transcriptional activation of the DNAHC7B gene. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol could induce DNAHC7B expression by its metabolite calcitriol binding to vitamin D receptors (VDR), which then form heterodimers with RXR and bind to vitamin D response elements near the DNAHC7B gene, stimulating transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may upregulate DNAHC7B by stimulating the expression of transcription factors specific to the DNAHC7B gene or by enhancing the acetylation state of histone proteins bound to the DNAHC7B promoter region. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could increase DNAHC7B expression through glucocorticoid receptor activation; the receptor-ligand complex may bind to glucocorticoid response elements in the DNAHC7B promoter, recruiting transcription factors to initiate mRNA synthesis. | ||||||