DHRS7C Inhibitors
Chemical inhibitors of DHRS7C can act through various mechanisms to impede its enzymatic function. Disulfiram, which traditionally targets aldehyde dehydrogenase, could inhibit DHRS7C by binding to its catalytic or structural zinc sites, thereby preventing the enzyme from performing its function. 4-Methylpyrazole, a known alcohol dehydrogenase inhibitor, can bind to the active site of DHRS7C, blocking substrate interaction and inhibiting the enzyme's activity due to structural and functional similarities. Menadione, acting as a pro-oxidant, can disrupt the redox state necessary for DHRS7C function, indirectly leading to its inhibition.
Methimazole, which inhibits enzymes with prosthetic heme groups, could exert an inhibitory effect on DHRS7C if it relies on similar groups for its activity. Trichostatin A and Valproic acid, both histone deacetylase inhibitors, can modify the acetylation patterns of proteins, potentially affecting the structure and function of DHRS7C. Chlorpromazine, with its ability to bind various enzymes, could inhibit DHRS7C by interacting with its active or allosteric sites, whereas phenylbutazone might inhibit the enzyme's oxidoreductive function by a similar mechanism of active site binding or electron transfer interference. Tolbutamide, through its ability to inhibit various enzymes, could also obstruct the catalytic function of DHRS7C upon binding to its active site. Sulfaphenazole and miconazole, which target cytochrome P450 enzymes, can inhibit DHRS7C by disrupting the enzymes that might be essential for the co-factor regeneration that DHRS7C requires, leading to an indirect reduction in its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram is an inhibitor of aldehyde dehydrogenase; it can bind to the catalytic and structural zinc sites of enzymes. Given that DHRS7C has dehydrogenase activity, disulfiram may inhibit DHRS7C by binding to similar sites. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $75.00 | 1 | |
Fomepizole is a known inhibitor of alcohol dehydrogenase. It acts by binding to the enzyme’s active site, preventing substrate interaction. Since DHRS7C shares functional similarities, 4-methylpyrazole could inhibit DHRS7C by a similar mechanism. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Menadione is a pro-oxidant which can deplete cellular antioxidants. It may indirectly inhibit DHRS7C by interfering with the redox state, which is necessary for the catalytic activity of many dehydrogenases. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Methimazole is a thiourea derivative that may inhibit peroxidase or other enzymes containing a prosthetic heme group. Similar inhibition could occur with DHRS7C if the protein relies on similar prosthetic groups for its activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By altering acetylation patterns, it could affect the function of proteins including dehydrogenases like DHRS7C by modifying their expression or structure. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine has aliphatic side-chain and can bind to various enzymes, potentially altering their function. DHRS7C, due to its enzymatic nature, could be inhibited by the binding of chlorpromazine to its active site or allosteric sites. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is known to inhibit histone deacetylase. It may indirectly affect DHRS7C by changing the acetylation status of proteins, which could influence its enzymatic activity. | ||||||
Phenylbutazone | 50-33-9 | sc-204843 | 5 g | $32.00 | 1 | |
Phenylbutazone can inhibit certain oxidoreductases. It might interact with DHRS7C and inhibit its oxidoreductive function by binding to its active site or interfering with its electron transfer processes. | ||||||
Tolbutamide | 64-77-7 | sc-203298 | 5 g | $44.00 | 2 | |
Tolbutamide is a sulfonylurea that can inhibit various enzymes. It may inhibit DHRS7C activity if it can bind to or near the active site, thereby obstructing the catalytic function of the enzyme. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Miconazole inhibits cytochrome P450-dependent enzymes which could be essential for the co-factor regeneration DHRS7C might require. By inhibiting these enzymes, miconazole could indirectly inhibit the activity of DHRS7C. | ||||||