Date published: 2025-9-13

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 31 to 40 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Chloranil

118-75-2sc-252566
25 g
$35.00
(0)

Chloranil is a versatile derivatization agent characterized by its strong electron-accepting properties due to the presence of multiple carbonyl groups. This compound readily participates in nucleophilic addition reactions, enabling the formation of stable derivatives through conjugate addition pathways. Its planar structure and delocalized π-electron system enhance reactivity, allowing for selective interactions with various nucleophiles. Chloranil's unique ability to facilitate oxidative transformations further expands its utility in synthetic applications.

Perylene

198-55-0sc-206007
sc-206007A
1 g
5 g
$51.00
$160.00
(0)

Perylene serves as a potent derivatization agent, notable for its robust π-π stacking interactions and high electron mobility. Its planar, aromatic structure allows for effective coordination with electrophiles, promoting rapid reaction kinetics. Perylene's ability to form stable charge-transfer complexes enhances its reactivity, making it suitable for diverse synthetic pathways. Additionally, its strong fluorescence properties can be exploited for monitoring reaction progress, providing insights into molecular interactions.

Fluorotriphenylsilane

379-50-0sc-263335
5 g
$116.00
(0)

Fluorotriphenylsilane is a versatile derivatization agent characterized by its unique silicon-fluorine bond, which enhances reactivity through strong electrophilic character. Its bulky triphenyl groups provide steric hindrance, facilitating selective reactions and improving yields. The compound exhibits notable stability under various conditions, allowing for controlled reaction environments. Its ability to form stable siloxane linkages further expands its utility in synthetic chemistry, enabling intricate molecular modifications.

Trichloro(3,3,3-trifluoropropyl)silane

592-09-6sc-237273
25 ml
$108.00
(0)

Trichloro(3,3,3-trifluoropropyl)silane serves as a potent derivatization agent, distinguished by its trifluoropropyl group that imparts unique hydrophobic properties and enhances molecular interactions. The presence of multiple chlorine atoms increases electrophilicity, promoting rapid reaction kinetics with nucleophiles. This compound's ability to form robust silane bonds allows for effective surface modifications, making it ideal for tailoring material properties in various applications.

Trichloro(3-cyanopropyl)silane

1071-27-8sc-253740
sc-253740A
25 g
100 g
$60.00
$184.00
(0)

Trichloro(3-cyanopropyl)silane is a versatile derivatization agent characterized by its cyanopropyl moiety, which introduces polar functional groups that enhance solubility in various solvents. Its trichloro substituents significantly elevate its reactivity, facilitating swift nucleophilic attacks. The compound's unique ability to form stable siloxane linkages enables precise modifications of surfaces, allowing for tailored interactions and improved adhesion properties in diverse chemical environments.

4-(4-Nitrobenzyl)pyridine

1083-48-3sc-256628
sc-256628A
sc-256628B
5 g
25 g
250 g
$43.00
$149.00
$823.00
(0)

4-(4-Nitrobenzyl)pyridine serves as a potent derivatization agent, distinguished by its nitrobenzyl group that enhances electron-withdrawing capabilities. This feature promotes selective electrophilic reactions, enabling the formation of stable adducts through robust π-π stacking interactions. Its pyridine nitrogen can engage in hydrogen bonding, facilitating complexation with various substrates. The compound's unique reactivity profile allows for efficient modifications, optimizing analytical techniques and enhancing detection sensitivity.

Dichlorodiethylsilane

1719-53-5sc-234595
sc-234595B
sc-234595C
5 g
100 g
1 kg
$62.00
$500.00
$2115.00
(0)

Dichlorodiethylsilane acts as a versatile derivatization agent, characterized by its ability to form siloxane bonds through nucleophilic substitution reactions. The presence of chlorine atoms enhances its reactivity, allowing for rapid attachment to various functional groups. This compound exhibits unique steric properties that influence reaction kinetics, promoting selective derivatization pathways. Its hydrophobic nature aids in the stabilization of intermediates, making it effective for enhancing the resolution of complex mixtures in analytical applications.

2,3,4,5,6-Pentafluorobenzhydrol

1944-05-4sc-213972
5 g
$122.00
(0)

2,3,4,5,6-Pentafluorobenzhydrol serves as a potent derivatization agent, notable for its strong electron-withdrawing fluorine substituents that enhance electrophilicity. This compound facilitates the formation of stable adducts through hydrogen bonding and π-π stacking interactions, promoting selective reactions with nucleophiles. Its high polarity and low volatility contribute to improved solubility in polar solvents, optimizing reaction conditions and enhancing product yields in analytical chemistry.

1,1-Dichlorosilacyclobutane

2351-33-9sc-224836
5 ml
$124.00
(0)

1,1-Dichlorosilacyclobutane is a versatile derivatization agent characterized by its unique silacyclobutane framework, which allows for effective cross-linking and stabilization of reactive intermediates. Its dichloro substituents enhance electrophilic reactivity, enabling selective interactions with nucleophiles. The compound's ability to form stable siloxane bonds facilitates the creation of complex derivatives, while its distinct steric properties influence reaction kinetics, promoting efficient pathways in synthetic applications.

Chloromethyl methyl sulfide

2373-51-5sc-252589
sc-252589A
5 g
25 g
$38.00
$120.00
(0)

Chloromethyl methyl sulfide serves as a potent derivatization agent, distinguished by its reactive chloromethyl group that readily engages in nucleophilic substitution reactions. This compound exhibits unique reactivity due to the presence of sulfur, which can stabilize intermediates through resonance effects. Its ability to form thioether linkages enhances the diversity of derivatives, while the steric hindrance from the methyl group influences selectivity and reaction rates, making it a valuable tool in synthetic chemistry.