Date published: 2025-9-12

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 101 to 110 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

69304-37-6sc-251584
1 g
$58.00
(0)

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane serves as a versatile derivatization agent, notable for its ability to introduce chlorinated siloxane functionalities into organic compounds. Its unique structure promotes selective reactivity with nucleophiles, enabling the formation of stable siloxane derivatives. The presence of isopropyl groups enhances steric hindrance, influencing reaction kinetics and selectivity, while its siloxane backbone contributes to improved thermal stability and solubility in various solvents.

2-(Trimethylsilyl)ethoxymethyl chloride

76513-69-4sc-251682
sc-251682A
1 g
5 g
$42.00
$142.00
(0)

2-(Trimethylsilyl)ethoxymethyl chloride is a specialized derivatization agent that facilitates the introduction of trimethylsilyl and ethoxymethyl groups into target molecules. Its reactivity is characterized by the formation of stable ether linkages through nucleophilic substitution, driven by the electrophilic nature of the chloride. The trimethylsilyl moiety enhances the lipophilicity and volatility of derivatives, while also providing protection against hydrolysis, making it a valuable tool in synthetic organic chemistry.

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine

93102-05-7sc-255327
sc-255327A
5 g
25 g
$129.00
$522.00
(0)

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine serves as a versatile derivatization agent, enabling the modification of amine functionalities. Its unique structure promotes selective interactions with electrophiles, facilitating the formation of stable amine derivatives. The presence of the trimethylsilyl group enhances the compound's hydrophobic characteristics, improving the stability of the resulting derivatives under various conditions. This agent's reactivity is further influenced by steric factors, allowing for tailored synthesis pathways in complex organic transformations.

1-(3-Bromo-1-propynyl)naphthalene

352035-98-4sc-253867
1 g
$136.00
(0)

1-(3-Bromo-1-propynyl)naphthalene serves as a versatile derivatization agent, notable for its ability to engage in electrophilic aromatic substitution reactions. The presence of the bromopropynyl group enhances its reactivity, allowing for selective modifications of nucleophilic sites on target molecules. This compound exhibits unique molecular interactions that facilitate the formation of stable adducts, optimizing reaction kinetics and enabling efficient pathways for complex chemical transformations. Its distinct structural features contribute to its effectiveness in various analytical applications.

Methyltrichlorosilane

75-79-6sc-250402
100 g
$45.00
(0)

Methyltrichlorosilane is a potent derivatization agent characterized by its ability to form siloxane bonds through nucleophilic attack. Its high reactivity stems from the presence of three chlorines, which facilitate rapid substitution reactions with hydroxyl groups, leading to the formation of silane derivatives. This compound's unique molecular interactions promote the creation of robust siloxane networks, enhancing stability and specificity in chemical transformations. Its distinctive properties make it a key player in modifying surfaces and enhancing material characteristics.

Chlorotriphenylsilane

76-86-8sc-239538
5 g
$21.00
(0)

Chlorotriphenylsilane serves as an effective derivatization agent, notable for its ability to engage in electrophilic reactions due to the presence of the reactive chlorosilane group. This compound exhibits a propensity for forming stable covalent bonds with nucleophiles, enabling selective modifications of functional groups. Its unique steric and electronic properties facilitate the formation of complex silane derivatives, enhancing the specificity and efficiency of chemical transformations in various applications.

Trichlorocyclohexylsilane

98-12-4sc-229562
5 g
$41.00
(0)

Trichlorocyclohexylsilane is a versatile derivatization agent characterized by its unique cyclohexyl structure, which imparts distinct steric hindrance and electronic effects. This compound readily participates in nucleophilic substitution reactions, allowing for the formation of robust siloxane linkages. Its reactivity is enhanced by the presence of multiple chlorosilane groups, promoting efficient functionalization of substrates. The compound's ability to stabilize intermediates through steric interactions makes it a valuable tool in synthetic chemistry.

3,5-Dinitrobenzoyl chloride

99-33-2sc-252064
sc-252064A
25 g
100 g
$38.00
$102.00
(0)

3,5-Dinitrobenzoyl chloride serves as a potent derivatization agent, notable for its electron-withdrawing nitro groups that enhance electrophilicity. This compound readily engages in acylation reactions, facilitating the formation of stable amides and esters. Its aromatic structure contributes to unique π-π stacking interactions, which can influence reaction kinetics and selectivity. The presence of the acid chloride functional group allows for rapid and efficient transformations, making it a key player in organic synthesis.

3,4-Dihydro-2H-pyran

110-87-2sc-256581
sc-256581A
100 ml
500 ml
$28.00
$126.00
(0)

3,4-Dihydro-2H-pyran is an effective derivatization agent characterized by its cyclic ether structure, which promotes nucleophilic attack due to its electron-rich nature. This compound can undergo ring-opening reactions, facilitating the formation of diverse derivatives. Its unique ability to stabilize intermediates through intramolecular interactions enhances reaction rates and selectivity. Additionally, the presence of the double bond allows for further functionalization, expanding its utility in organic synthesis.

Ethyltrichlorosilane

115-21-9sc-239972
25 g
$27.00
(0)

Ethyltrichlorosilane serves as a versatile derivatization agent, notable for its reactivity as a silicon-based compound. Its electrophilic nature allows for efficient nucleophilic substitution reactions, enabling the formation of siloxane bonds. The presence of three chlorine atoms enhances its ability to engage in hydrolysis, leading to the generation of silanol groups. This reactivity facilitates the modification of surfaces and the creation of silane-based networks, making it a key player in material science applications.