Delta-3 Activators
Indirect modulation of DLL3 often revolves around the manipulation of the Notch signaling pathway, to which DLL3 belongs. Researchers explore various compounds, including gamma-secretase inhibitors, HDAC inhibitors, and DNA methyltransferase inhibitors, to influence the overall activity of the Notch pathway. These compounds do not activate DLL3 directly but rather affect DLL3's interactions with Notch receptors and downstream signaling by altering the processing, expression, or epigenetic regulation of Notch pathway components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a gamma-secretase inhibitor. It indirectly affects DLL3 by modulating the Notch signaling pathway. DLL3 is one of the ligands in the Notch pathway, and its activation depends on cleavage by gamma-secretase. DAPT inhibits gamma-secretase, preventing the cleavage of Notch receptors and downstream signaling, which indirectly affects DLL3's interactions with Notch receptors. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $439.00 $1417.00 | 1 | |
RO4929097 is another gamma-secretase inhibitor. Like DAPT, it indirectly impacts DLL3 by modulating the Notch signaling pathway. By inhibiting gamma-secretase, RO4929097 alters Notch receptor cleavage and activation, which subsequently influences DLL3's interactions with Notch receptors and downstream signaling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is an HDAC (histone deacetylase) inhibitor. It indirectly affects DLL3 by potentially altering the acetylation status of histones. This epigenetic modulation can indirectly impact Notch pathway gene expression, including DLL3, and affect DLL3's role within the Notch signaling pathway. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It can indirectly affect DLL3 by influencing DNA methylation patterns. Changes in DNA methylation can impact gene expression, including that of DLL3, and subsequently affect DLL3's interactions with Notch receptors and downstream Notch signaling. | ||||||