DCC1 Activators

DCC1, known as DNA replication and sister chromatid cohesion 1, is a protein associated with the maintenance of genomic stability, a critical aspect of cellular function and integrity. It is encoded by the gene DCC1, which is located on chromosome 17 in humans.The protein DCC1 plays a pivotal role in the establishment of sister chromatid cohesion during DNA replication. Sister chromatid cohesion is essential for accurate chromosome segregation during cell division, as it ensures that each daughter cell receives an identical set of chromosomes. DCC1 is a subunit of the cohesion establishment complex, which also includes proteins such as CTF8 and CTF18. This complex is thought to act in parallel with the cohesin complex, which directly mediates the cohesion of sister chromatids.

DCC1's function is intricately linked to the process of DNA replication, as the establishment of cohesion is closely coordinated with the replication fork. The cohesion complex, including DCC1, is responsible for the recruitment of cohesin to newly replicated DNA and for regulating its function during the S phase of the cell cycle. By participating in this process, DCC1 helps to safeguard the correct alignment and separation of chromosomes, preventing aneuploidy and genomic instability, which are hallmarks of cancer and other genetic disorders.In addition to its role in sister chromatid cohesion, DCC1 is also involved in the DNA damage response. It is part of a mechanism that detects and repairs replication-associated DNA damage, further contributing to the maintenance of genomic stability.