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DAZAP2 Inhibitors

DAZAP2 inhibitors are a category of chemical compounds that specifically target and attenuate the activity of DAZAP2, a protein known to play a role in RNA binding and the regulation of gene expression. DAZAP2, or Deleted in Azoospermia Associated Protein 2, is part of a family of proteins involved in the regulation of mRNA metabolism, including splicing, transport, and stability. Inhibitors of DAZAP2 typically function by binding to the protein in such a way as to interfere with its ability to interact with mRNA or other proteins involved in the gene expression pathway. The inhibition may occur through direct competition with the mRNA binding sites on DAZAP2, or by inducing conformational changes in DAZAP2 that reduce its RNA binding affinity or disrupt its integration into larger protein-RNA complexes. The design of these inhibitors often takes advantage of the specific molecular structures and charge distributions involved in DAZAP2-RNA interactions, aiming to create high-affinity ligands that can outcompete natural RNA substrates or disrupt essential protein-protein interactions. The development of DAZAP2 inhibitors involves a combination of computational modeling and empirical biochemistry to understand the interaction dynamics between DAZAP2 and its inhibitors. High-resolution structural data of DAZAP2, obtained from methods like X-ray crystallography or NMR spectroscopy, are critical for mapping potential binding sites and understanding the spatial arrangement of amino acids that are key for the protein's function. Computational approaches, including molecular docking and virtual screening, can then be used to predict how potential inhibitors might interact with these binding sites. Once promising candidates are identified, they are synthesized and subjected to a series of biochemical assays to evaluate their binding affinity and inhibitory capacity.

Items 1 to 10 of 12 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
LY 294002	154447-36-6	sc-201426 sc-201426A	5 mg 25 mg	$123.00 $400.00	148	(1)
LY294002 is a potent inhibitor of PI3K, a kinase involved in numerous signaling pathways. PI3K can modulate the activity of several proteins, including those related to mRNA processing in which DAZAP2 may be involved. Inhibition of PI3K can alter the phosphorylation state and function of proteins downstream, potentially affecting DAZAP2's role in these processes.
Wortmannin	19545-26-7	sc-3505 sc-3505A sc-3505B	1 mg 5 mg 20 mg	$67.00 $223.00 $425.00	97	(3)
Wortmannin is another PI3K inhibitor known for its role in disrupting PI3K-dependent signaling pathways. By inhibiting PI3K, wortmannin can lead to reduced phosphorylation of downstream targets, which may alter the cellular localization or function of DAZAP2 if it is part of the PI3K signaling cascade.
PD 98059	167869-21-8	sc-3532 sc-3532A	1 mg 5 mg	$40.00 $92.00	212	(2)
PD98059 is an inhibitor of MEK, which is upstream of ERK in the MAPK signaling pathway. Since MAPK/ERK pathway can regulate various aspects of cell function including gene expression, PD98059 might affect the cellular context in which DAZAP2 operates, possibly impacting its RNA-binding activity.
SP600125	129-56-6	sc-200635 sc-200635A	10 mg 50 mg	$40.00 $150.00	257	(3)
SP600125 inhibits JNK, which is part of the MAPK family. JNK pathway affects transcription factors and thus gene expression. By inhibiting JNK, SP600125 might influence the expression levels or activity of DAZAP2 indirectly.
SB 203580	152121-47-6	sc-3533 sc-3533A	1 mg 5 mg	$90.00 $349.00	284	(5)
SB203580 is a selective inhibitor of p38 MAPK. The p38 MAPK pathway is implicated in the regulation of mRNA stability and translation, two processes where DAZAP2 might play a role. Inhibition of p38 MAPK could therefore impact DAZAP2 function in mRNA metabolism.
U-0126	109511-58-2	sc-222395 sc-222395A	1 mg 5 mg	$64.00 $246.00	136	(2)
U0126 is an inhibitor of MEK1/2, key components of the MAPK/ERK pathway. By inhibiting MEK1/2, U0126 can decrease ERK activity which may affect transcriptional regulation and other cellular processes that could influence DAZAP2′s function.
Rapamycin	53123-88-9	sc-3504 sc-3504A sc-3504B	1 mg 5 mg 25 mg	$63.00 $158.00 $326.00	233	(4)
Rapamycin inhibits mTOR, which is part of the PI3K/AKT/mTOR pathway, a central pathway in regulating cell growth and proliferation. mTOR inhibition can lead to broad changes in mRNA translation and protein synthesis, which may affect DAZAP2's involvement in these processes.
PP 2	172889-27-9	sc-202769 sc-202769A	1 mg 5 mg	$94.00 $227.00	30	(1)
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can influence various signaling pathways, including those that regulate RNA splicing and processing, where DAZAP2 may be active. By inhibiting Src kinases, PP2 might impact DAZAP2's associated pathways.
Y-27632, free base	146986-50-7	sc-3536 sc-3536A	5 mg 50 mg	$186.00 $707.00	88	(1)
Y-27632 is an inhibitor of ROCK, which plays a role in cytoskeleton dynamics. Since DAZAP2 has been implicated in mRNA transport, which can be cytoskeleton-dependent, Y-27632 might indirectly affect DAZAP2's function in this regard.
KN-93	139298-40-1	sc-202199	1 mg	$182.00	25	(1)
KN-93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). CaMKII regulates various cellular functions, including mRNA processing. Inhibition of CaMKII might influence the activity or regulation of DAZAP2.

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DAZAP2 Inhibitors

LY 294002

Wortmannin

PD 98059

SP600125

SB 203580

U-0126

Rapamycin

PP 2

Y-27632, free base

KN-93