D10Jhu81e Activators
Gatd3a, a protein predominantly located in the mitochondria, emerges as a key player in orchestrating cellular homeostasis across various tissues. Its diverse expression in structures such as the genitourinary system, gut, nervous system, sensory organs, and thymus underscores its significance in maintaining cellular processes critical for overall tissue functionality. The predicted functions of Gatd3a involve its participation in the constitutive secretory pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, and the regulation of protein complex stability. Moreover, Gatd3a is implicated in the pathogenesis of autosomal recessive limb-girdle muscular dystrophy type 2S, further emphasizing its crucial role in physiological processes.
Activation of Gatd3a involves intricate cellular mechanisms mediated by a variety of chemicals. These compounds act as direct or indirect activators, influencing Gatd3a's activity through modulation of specific pathways and cellular processes. For instance, some chemicals directly activate Gatd3a by stimulating AMP-activated protein kinase (AMPK) signaling, leading to phosphorylation and subsequent enhancement of mitochondrial functions. Others indirectly activate Gatd3a by inhibiting mTOR signaling, thereby relieving suppression on Gatd3a and promoting its mitochondrial localization. The actions of these chemicals extend to structures such as the gut, thymus, and sensory organs, showcasing the broad impact of Gatd3a in maintaining cellular homeostasis. The diverse mechanisms of Gatd3a activation, influenced by distinct chemical regulators, contribute to its pivotal role in sustaining cellular processes across multiple tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR directly activates Gatd3a by stimulating AMP-activated protein kinase (AMPK) signaling. AICAR activates AMPK, leading to phosphorylation and activation of Gatd3a. This enhances mitochondrial functions, promoting the target's activity in various structures, including the genitourinary system and nervous system. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin indirectly activates Gatd3a by inhibiting mTOR signaling. mTOR inhibition by Rapamycin relieves suppression on Gatd3a, enhancing its mitochondrial localization and activity. This positively impacts structures like the gut and thymus, where Gatd3a plays a crucial role in maintaining cellular functions. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic Acid directly activates Gatd3a by enhancing its mitochondrial functions. This antioxidant promotes Gatd3a activity, influencing cellular structures such as the sensory organs. Alpha-Lipoic Acid's impact on mitochondrial metabolism contributes to the upregulation of Gatd3a and its diverse roles in various tissues. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin directly activates Gatd3a by modulating AMP-activated protein kinase (AMPK) signaling. Metformin activates AMPK, leading to the phosphorylation and activation of Gatd3a. This promotes mitochondrial activity in tissues like the genitourinary system and nervous system, contributing to cellular homeostasis. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
Carnitine directly activates Gatd3a by enhancing mitochondrial functions. By facilitating fatty acid transport into mitochondria, Carnitine promotes Gatd3a activity, influencing structures like the gut and thymus. This metabolic activator supports Gatd3a in maintaining cellular processes critical for overall tissue functionality. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 directly activates Gatd3a by supporting mitochondrial functions. CoQ10 enhances Gatd3a activity, impacting structures such as the sensory organs. Its role in mitochondrial electron transport contributes to the upregulation of Gatd3a, promoting cellular homeostasis in diverse tissues. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $60.00 $125.00 | 5 | |
Dichloroacetic acid directly activates Gatd3a by modulating mitochondrial metabolism. DCA promotes Gatd3a activity, influencing cellular structures like the genitourinary system and nervous system. Its impact on mitochondrial processes contributes to the upregulation of Gatd3a and its crucial roles in various tissues. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine directly activates Gatd3a by modulating AMP-activated protein kinase (AMPK) signaling. Berberine activates AMPK, leading to the phosphorylation and activation of Gatd3a. This enhances mitochondrial functions, positively impacting structures such as the gut and thymus where Gatd3a plays a vital role in maintaining cellular processes. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylate directly activates Gatd3a by influencing mitochondrial functions. Salicylate enhances Gatd3a activity, impacting cellular structures like the sensory organs. Its role in mitochondrial processes contributes to the upregulation of Gatd3a, promoting cellular homeostasis in various tissues. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine directly activates Gatd3a by supporting mitochondrial functions. NAC enhances Gatd3a activity, influencing structures like the genitourinary system and nervous system. Its role in mitochondrial antioxidant defense contributes to the upregulation of Gatd3a, promoting cellular homeostasis. | ||||||